[GRG] NewAbs: Metformin Inhibits NF-kB

To Members and Friends of the Los Angeles Gerontology
Research Group:  Metformin
inhibits NF-kB… — Steve Coles

“Anti-Inflammatory Mechanism Found
for Metformin”

March 29, 2013; (LEF) — In an article appearing on March
23, 2013 in the journal

Aging Cell, researchers at the University of Montreal report
that metformin, a drug used to treat

diabetes, decreases the production of inflammatory cytokines which,
when produced in excess, result in damaging inflammation that increases
the risk of cancer and other diseases.Dr.
Gerardo Ferbeyre of the University?s Department of Biochemistry and his
associates discovered that metformin inhibits the expression of genes
that code for a number of inflammatory cytokines observed during cellular
senescence. “Cells normally secrete these inflammatory cytokines
when they need to mount an immune response to infection, but chronic
production of these same cytokines can also cause cells to age,? Dr
Ferbeyre explained. ?Such

chronic inflammation can be induced, for example by smoking.”
“We
were surprised by our finding that metformin could prevent the production
of inflammatory cytokines by old cells.”The
researchers uncovered evidence that metformin blocks the activity of a
transcription factor known as nuclear factor kappa-beta (NF-kB),
which is involved in inflammation. “The genes that code for
cytokines are normal, but a protein that normally triggers their
activation called NF-kB can’t reach them in the cell nucleus in
metformin treated cells”, Dr Ferbeyre observed. “We also found
that metformin does not exert its effects through a pathway commonly
thought to mediate its antidiabetic effects.””This is an important finding with implications for our
understanding on how the normal organism defends itself from the threat
of cancer and how a very common and safe drug may aid in treatment of
some cancers and perhaps slow down the

aging process,? he added. ?It remains that determining the specific
targets of metformin would give us an even better opportunity to profit
from its beneficial effects. That’s what we want to figure out
next.”
L. Stephen Coles, M.D., Ph.D., Co-Founder
Los Angeles Gerontology Research GroupURL:
http://www.grg.org
E-mail: scoles@grg.orgE-mail:
scoles@ucla.edu

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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