[GRG] NewAbs: Mouse Model of AD with Magnesium

To Members and Friends of the Los Angeles Gerontology
Research Group:  Magnesium
in a mouse model of AD… — Steve Coles

“Researchers at University of Texas
Have Reported New Data on Alzheimer
Disease”

NewsRx.com by a News Reporter-Staff News Editor at Pain and
Central Nervous System Week — Current study results on Neurodegenerative
Diseases have been published.
June 28, 2013; (LEF) —  According to news reporting
originating from Austin, TX, by NewsRx correspondents, research
stated, “Profound synapse loss is one of the major
pathological hallmarks associated with Alzheimer’s Disease (AD) and might
underlie memory impairment. Our previous work demonstrated that the
magnesium ion is a critical factor in controlling synapse
density/plasticity.” Our news
Editors obtained a quote from the research from the University of Texas,
“Here, we investigated whether elevation of brain magnesium by the
use of a recently developed compound, magnesium-L-threonate (MgT), can
ameliorate the AD-like pathologies and cognitive deficits in the
APPswe/PS1dE9 mice, a transgenic (Tg) mouse model of AD.  MgT
treatment reduced A-beta plaque and prevented synapse loss and memory
decline in the Tg mice. Strikingly, MgT treatment was effective even when
given to the mice at the end stage of their AD-like pathological
progression. To explore how elevation of brain magnesium ameliorates the
AD-like pathologies in the brains of Tg mice, we studied molecules
critical for APP metabolism and signaling pathways implicated in synaptic
plasticity/density. In the Tg mice, the NMDAR/CREB/BDNF signaling was
down-regulated, whereas calpain/calcineurin/Cdk5 neurodegenerative
signaling and beta-secretase (BACE1) expression were up-regulated. MgT
treatment prevented the impairment of these signaling pathways,
stabilized BACE-1 expression, and reduced soluble APP beta and
beta-C-terminal fragments in the Tg mice. At the molecular level,
elevation of extracellular magnesium prevented the high- A-beta-induced
reductions in synaptic NMDAR’s by preventing calcineurin overactivation
in hippocampal slices. Correlation studies suggested that the protection
of NMDAR signaling might underlie the stabilization of BACE-1
expression.” According
to the news Editors, the research concluded, “Our results suggest
that elevation of brain magnesium exerts substantial synapto-protective
effects in a mouse model of AD and may have therapeutic potential for
treating AD in humans.”

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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