[GRG] NewAbs: Telomeres and Cancer (N-cadherin)

To Members and Friends of the Los Angeles Gerontology
Research Group:Telomeres
and cancer… — Steve Coles

“Telomere Length Influences Cancer
Cell Differentiation”
Friday June, 28, 2013; (Bioscience and Technology) — Researchers
from the Japanese Foundation for Cancer Research in Tokyo have discovered
that forced elongation of telomeres (extensions on the end of
chromosomes) promotes the differentiation of cancer cells, probably
reducing malignancy, which is strongly associated with a loss of cell
differentiation.  They report their findings in a manuscript
published on-line ahead of print, in the journal Molecular and
Cellular Biology.?Cancer
cells may maintain short telomeres to maintain their undifferentiated
state,? says Hiroyuki Seimiya, a researcher on the study.  Telomeres
are protective extensions on the ends of chromosomes, which shorten as
cells age, like an hourglass running down. They protect the end of the
chromosome from deterioration or from fusion with neighboring
chromosomes. Without telomeres chromosomes would progressively lose
genetic information as cells divide and replicate.Cancer
cells, on the other hand, may have shorter telomeres compared to healthy
cells, but they guard their immortality by maintaining these telomeres?
length using telomerase.In the
study, the forced elongation of cancer cells? telomeres suppressed a
number of genes and proteins that appear to be involved in tumor
malignancy, according to the report. For example, one of these factors,
N-cadherin, is involved in prostate-cancer metastasis.Based on
their results, the investigators now propose that telomeres also
modulate the behavior of cells by controlling gene expression, “by
as yet unknown mechanisms,” says Seimiya. His research, he says,
may ultimately lead to new types of treatments for cancer. A copy of the
manuscript can be found on-line at
http://bit.ly/asmtip0613d. Formal
publication is scheduled for the August 2013 issue of Molecular and
Cellular Biology.Source:

American Society for Microbiology



L. Stephen Coles, M.D., Ph.D., Co-Founder
Los Angeles Gerontology Research GroupURL:
E-mail: scoles@grg.orgE-mail:


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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