Well, you have to hand it to these researchers. If this works, somebody will
try to come up with a 50 mg oral testosterone pill, and sell it for a lot of
money. And somebody else will just point out that you should just be able to
instead swallow some 1.62% androgel and get the same effect. How much?
Well, 1.62% is 1620 mg per 100 g or 16 mg per gram of gel, which would
require swallowing 3 grams of gel. I wonder how it tastes?
Compounding pharmacies can make up to 10% testosterone gel, which would
require swallowing only 0.5 g to get 50 mg. Just a dab.
Going in the other direction, it’s rather amazing that we don’t yet have a
testosterone lollypop, for those who want to use pure T gels to bypass the
liver. Supposedly, this works as well as transdermal, or better.
Here’s a study from 12 years ago:
Fertil Steril. 2001 Jul;76(1):32-7.
Pharmacokinetics of testosterone after percutaneous gel or buccal
Slater CC, Souter I, Zhang C, Guan C, Stanczyk FZ, Mishell DR.
Department of Obstetrics and Gynecology, University of Southern California,
School of Medicine, Los Angeles, California, USA. firstname.lastname@example.org
OBJECTIVE: To determine the pharmacokinetics of testosterone following its
administration using transdermal gel or buccal lozenges.
DESIGN: Pilot study.
SETTING: University-based hospital.
PATIENT(S): Ten bilaterally oophorectomized women.
INTERVENTION(S): Daily micronized testosterone gel (1 mg) and testosterone
propionate lozenge (1 mg).
MAIN OUTCOME MEASURE(S): Total testosterone, androstenedione,
dihydrotestosterone, 3alpha-androstanediol glucuronide, and sex
globulin were measured in serum by specific radioimmunoassays; free
levels were also calculated.
RESULT(S): Before treatment, serum testosterone levels in the groups using
lozenge and gel were 16 +/- 4.0 and 20 +/- 6.0 ng/dL, respectively. Mean
testosterone levels obtained with the lozenge occurred 1 hour after
administration on days 1 (692 +/- 236 ng/dL) and 14 (836 +/- 309 ng/dL) of
treatment and fell precipitously thereafter. In contrast, testosterone
obtained with the gel showed a prolonged rise reaching maximal levels of 97
78 and 100 +/- 60 ng/dL after 18 hours. The serum level patterns of free
testosterone, dihydrotestosterone, and 3alpha-androstanediol glucuronide
similar to the corresponding total testosterone levels.
CONCLUSION(S): Administration of testosterone lozenge by buccal absorption
produced a rapid and brief elevation of testosterone levels, with levels
upper limits of the male range. In contrast, transdermal testosterone gel
absorption resulted in a prolonged elevation of testosterone levels, which
in the hyperandrogenic female range but resembled steady state
PMID: 11438316 [PubMed – indexed for MEDLINE]
Thus, a compounding pharmacy should be able to make testosterone skin gel
into a losenge that goes under the tongue to avoid hepatic metabolism. Or
the gel could probably be smeared on the gums (again, this is a taste
isssue, but compounders are good at adding tastes to oily preparations).
It’s just a matter of finding something that testosterone disolves in, and
then can be emulsified. You’d don’t necessarily need something that contains