Re: [GRG] NewAbs: Low Dose “T” To Block Sarcopenia in Both Men and Women

Well, you have to hand it to these researchers. If this works, somebody will
try to come up with a 50 mg oral testosterone pill, and sell it for a lot of
money. And somebody else will just point out that you should just be able to
instead swallow some 1.62% androgel and get the same effect. How much?
Well, 1.62% is 1620 mg per 100 g or 16 mg per gram of gel, which would
require swallowing 3 grams of gel. I wonder how it tastes?

Compounding pharmacies can make up to 10% testosterone gel, which would
require swallowing only 0.5 g to get 50 mg. Just a dab.

Going in the other direction, it’s rather amazing that we don’t yet have a
testosterone lollypop, for those who want to use pure T gels to bypass the
liver. Supposedly, this works as well as transdermal, or better.

Here’s a study from 12 years ago:

Fertil Steril. 2001 Jul;76(1):32-7.

Pharmacokinetics of testosterone after percutaneous gel or buccal
administration.

Slater CC, Souter I, Zhang C, Guan C, Stanczyk FZ, Mishell DR.

Department of Obstetrics and Gynecology, University of Southern California,
Keck

School of Medicine, Los Angeles, California, USA. coulam@hsc.usc.edu

OBJECTIVE: To determine the pharmacokinetics of testosterone following its

administration using transdermal gel or buccal lozenges.

DESIGN: Pilot study.

SETTING: University-based hospital.

PATIENT(S): Ten bilaterally oophorectomized women.

INTERVENTION(S): Daily micronized testosterone gel (1 mg) and testosterone

propionate lozenge (1 mg).

MAIN OUTCOME MEASURE(S): Total testosterone, androstenedione,

dihydrotestosterone, 3alpha-androstanediol glucuronide, and sex
hormone-binding

globulin were measured in serum by specific radioimmunoassays; free
testosterone

levels were also calculated.

RESULT(S): Before treatment, serum testosterone levels in the groups using
the

lozenge and gel were 16 +/- 4.0 and 20 +/- 6.0 ng/dL, respectively. Mean
maximum

testosterone levels obtained with the lozenge occurred 1 hour after

administration on days 1 (692 +/- 236 ng/dL) and 14 (836 +/- 309 ng/dL) of

treatment and fell precipitously thereafter. In contrast, testosterone
levels

obtained with the gel showed a prolonged rise reaching maximal levels of 97
+/-

78 and 100 +/- 60 ng/dL after 18 hours. The serum level patterns of free

testosterone, dihydrotestosterone, and 3alpha-androstanediol glucuronide
were

similar to the corresponding total testosterone levels.

CONCLUSION(S): Administration of testosterone lozenge by buccal absorption

produced a rapid and brief elevation of testosterone levels, with levels
reaching

upper limits of the male range. In contrast, transdermal testosterone gel

absorption resulted in a prolonged elevation of testosterone levels, which
were

in the hyperandrogenic female range but resembled steady state
pharmacokinetics.

PMID: 11438316 [PubMed – indexed for MEDLINE]

Thus, a compounding pharmacy should be able to make testosterone skin gel
into a losenge that goes under the tongue to avoid hepatic metabolism. Or
the gel could probably be smeared on the gums (again, this is a taste
isssue, but compounders are good at adding tastes to oily preparations).
It’s just a matter of finding something that testosterone disolves in, and
then can be emulsified. You’d don’t necessarily need something that contains
DMSO.

SBH

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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