Re: [GRG] Longevity and Healthspan (NECS)

Robert: Maybe should include Will Nelson in this discussion,
although I don’t know who he is.
You are quite correct that the simplified metaphor of “rusting”
(and presumably correcting it
with lubrication) is different for pipes vs. watches.  Let’s take
cars as an example.  Classic car
hobbyists do a lot more to their old cars to keep them going past 100,000
miles than routine
oil change and lubrication.   Correcting pathology may turn out
to be a lot more complex
than growing a brand-new organism from scratch.  Let’s ask Mrs. Ora
Holland. whose photo is
linked below, what she thinks. 🙂  — Steve Coles
At 06:37 PM 12/29/2013, you wrote:
Regarding Reason’s
oversimplification of the aging
      Everyone seems to be distracted by the
incredible complexity of the systems which sustain life…  and it’s
no wonder they are complex; they are the product of billions of years of
natural selection through evolution.  However, the modes of damage
operating in these systems were not subject to a process of selection.
AND WHY NOT? Wouldn’t processes that cause less damage favor longer-lived
individuals, at least to the point of reproductive success? Thus, there’s
no reason for them to be particularly complex.
      If your “if” statement is
incorrect, so would your “then” statement. So, it is a
conceptual mistake to argue that damage repair must be incredibly
complex, just because life systems are complex. Or, it’s a conceptual
mistake to argue that damage repair must be simple, simply because you
wish it to be.  
      By comparison with machinery, the same
rust affects both a simple metal pipe and a very complex Swiss watch. The
solution is the same for both, apply some rust-removing agents to each
      Another oversimplification that seeks to
define aging-related damage as just one, outside process, rather than
intrinsic damage within the system
      Currently, biologists mainly focus on
understanding every detail of the networks that give rise to life, but
most of this knowledge is bound to be irrelevant for damage repair. We’re
not trying to rebuild the system from scratch, just “remove the
rust.” The problem currently looks very hard, because few people are
studying the actual problem (rust removal).
      I’d like to be proven wrong, but I think a
lot of this is really wishful thinking. Even with Dr. Coles’s
clogged-pipes argument: suppose we find a treatment for the buildup of
amyloid proteins, and remove another cause of “premature”
death? All the other body systems in a 115-year-old have aged for 115
years, and something else will fail soon. All the systems are aging at
the same time. We see that the strategy of “longest-lived”
species, such as long-lived trees, is to grow new growth, not repair old
damage. Renewing old systems is far more complex than your simple rust
analogy allows.
      Take a look at this 113-year-old woman and
tell me that all we need to do for rejuvenation is to “remove
Robert Young
— Reason


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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