To Members and Friends of the Los Angeles Gerontology
Research Group: Human Gene
Knockout project… — Steve Coles
NEWS FOCUS: The Hunt for Missing GenesSummary:
is intrigued by the prospect that hidden in the human population are
people who lack certain genes yet remain healthy. Finding such natural
human “knockouts” and looking for differences between their
physiology and that of people with the intact gene may be the only way to
fully understand the function of many of our genes, he and others
contend. It could also have biomedical payoffs. To get started, MacArthur
and others want to comb through many thousands of people’s genomes for
missing genes to seed what MacArthur calls the Human Knockout Project.
But identifying dispensable genes is only the start of the challenge.
L. Stephen Coles, M.D., Ph.D., Co-Founder
Los Angeles Gerontology Research GroupURL: