[GRG] Regenerative Med: autologous stem cells can be rejected, but self-tolerance can be induced


(Regenerative Med: even autologous stem cells can be rejected, but
partially differentiating them makes the immune system of the
recipient more tolerant.)

Transplanted terminally differentiated induced pluripotent stem
cells are accepted by immune mechanisms similar to self-tolerance
Patricia .E de Almeida,
Everett H. Meyer,
Nigel G. Kooreman,
Sebastian Diecke,
Devaveena Dey,
Veronica Sanchez-Freire,
Shijun Hu,
Antje Ebert,
Justin Odegaard,
Nicholas M. Mordwinkin,
Thomas P. Brouwer,
David Lo,
Daniel T. Montoro,
Michael T. Longaker,
Robert S. Negrin
& Joseph C. Wu

The exact nature of the immune response elicited by autologous-
induced pluripotent stem cell (iPSC) progeny is still not well
understood. Here we show in murine models that autologous iPSC-
derived endothelial cells (iECs) elicit an immune response that
resembles the one against a comparable somatic cell, the aortic
endothelial cell (AEC). These cells exhibit long-term survival in
vivo and prompt a tolerogenic immune response characterized by
elevated IL-10 expression. In contrast, undifferentiated iPSCs
elicit a very different immune response with high lymphocytic
infiltration and elevated IFN-γ, granzyme-B and perforin
intragraft. Furthermore, the clonal structure of infiltrating T
cells from iEC grafts is statistically indistinguishable from that
of AECs, but is different from that of undifferentiated iPSC
grafts. Taken together, our results indicate that the
differentiation of iPSCs results in a loss of immunogenicity and
leads to the induction of tolerance, despite expected antigen
expression differences between iPSC-derived versus original somatic

About Johnny Adams

My full-time commitment is to slow and ultimately reverse biological aging and age related decline for more years of healthy living. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Aging Intervention Foundation (dba for Carl I. Bourhenne Medical Research Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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