Monthly Archives: June 2014

Re: [GRG] Library of All Possible Drug-Like Compounds

I assume that “1060 structures” is actually “10^60”, but did not come through because you are not using html email, as I suggested to avoid such problems. –Paul Wakfer On 06/29/2014 03:58 PM, regene1@hushmail.com wrote: > http://ift.tt/1bWpHp2 > > > … Continue reading

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[GRG] adult pluripotent stem cells are located throughout the body, need instructions

http://ift.tt/1qs2F4D Two sides of the same coin: stem cells in cancer and regenerative medicine Matthias Ilmer*, Jody Vykoukal*, Alejandro Recio Boiles*, Michael Coleman‡ and Eckhard Alt†§,1 + Author Affiliations *Department of Translational Molecular Pathology and †Center for Stem Cell and … Continue reading

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[GRG] bio-printed vascular networks have been achieved bringing 3-D printing of organs closer

http://ift.tt/1x4Ohjo Contact: Dan Gaffney daniel.gaffney@sydney.edu.au 61-408-004-782 University of Sydney A step closer to bio-printing transplantable tissues and organs: Study Researchers have made a giant leap towards the goal of ‘bio- printing’ transplantable tissues and organs for people affected by major … Continue reading

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[GRG] GRG meeting tonight — Steve Coles has returned

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[GRG] Library of All Possible Drug-Like Compounds

http://ift.tt/1bWpHp2 Stochastic Voyages into Uncharted Chemical Space Produce a Representative Library of All Possible Drug-Like Compounds Aaron M. Virshup †§, Julia Contreras-García †§, Peter Wipf ‡§, Weitao Yang *†§, and David N. Beratan *†§ J. Am. Chem. Soc., 2013, 135 … Continue reading

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[GRG] sequencing of normal cells reveals each cell’s life history

http://ift.tt/1pF4HPp. html Genome sequencing of normal cells reveals developmental lineages and mutational processes Sam Behjati, Meritxell Huch, Ruben van Boxtel, Wouter Karthaus, David C. Wedge, Asif U. Tamuri, Iñigo Martincorena, Mia Petljak, Ludmil B. Alexandrov, Gunes Gundem, Patrick S. Tarpey, … Continue reading

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Re: [GRG] Next GRG meeting Monday June 30, and Steve Coles traveling and comp…

  Hi Johnny.   All the best for your presentation tomorrow.  Sure wish I could be there.  I tried to reschedule, but sadly it would inconvenience too many people too much.   I can’t wait to see the video.   Carl   … Continue reading

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[GRG] Centenarians in South Australia

Greetings, This article appeared in our local newspaper last week:http://ift.tt/1pF4H1J It details the increase in the numbers of centenarians in South Australia from 185 women and 48 men in 2003 to 269 women and 77 men in 2013. The population … Continue reading

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[GRG] Reg. Med: Blocking key enzyme, Cdk5, minimizes stroke injury

http://ift.tt/LWhE5k 2014/june/stroke-bibb.html Blocking key enzyme minimizes stroke injury Dr. James Bibb, Associate Professor of Neurology and Neurotherapeutics Dr. James Bibb, Associate Professor of Neurology and Neurotherapeutics DALLAS – June 26, 2014 – A drug that blocks the action of the … Continue reading

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[GRG] A Selective Mitochondrial-Targeted Chlorambucil with Remarkable Cytotoxicity in Breast and Pancreatic Cancers

Nitrogen mustards, widely used as chemotherapeutics, have limited safety and efficacy. Mitochondria lack a functional nucleotide excision repair mechanism to repair DNA adducts and are sensitive to alkylating agents. Importantly, cancer cells have higher intrinsic mitochondrial membrane potential (Δψmt) than … Continue reading

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