[GRG] longevity factor identified for the naked mole rat


SAN ANTONIO (Aug. 29, 2014) — Scientists at the Barshop Institute
for Longevity and Aging Studies, part of the School of Medicine at
the UT Health Science Center at San Antonio, have found another
secret of longevity in the tissues of the longest-lived rodent, the
naked mole rat.
They reported that a factor in the cells of naked mole rats
protects and alters the activity of the proteasome, a garbage
disposer for damaged and obsolete proteins.
The factor also protects proteasome function in human, mouse and
yeast cells when challenged with various proteasome poisons,
studies showed. These proteasomes usually rapidly stop functioning,
leading to the accumulation of damaged proteins that further impair
cell function, contributing to the vicious cycle that leads to cell
“I think this factor is part of an overall process or mechanism by
which naked mole rats maintain their protein quality,” study first
author Karl Rodriguez, Ph.D., said.
Generally, as an organism ages, not only are there more damaged
proteins in need of disposal, but the proteasome itself becomes
damaged and less efficient in clearing out the damaged proteins.
As a result, protein quality declines and this contributes to the
functional declines seen during aging. Enhancement of protein
quality, meanwhile, leads to longer life in yeast, worms, fruit
flies and naked mole rats, Dr. Rodriguez said.
Dr. Rodriguez, a San Antonio native who completed both his master’s
and doctoral degrees at the Health Science Center, is a
postdoctoral fellow in the laboratory of Rochelle Buffenstein,
Ph.D., professor of physiology at the Barshop Institute. For this
study, the Buffenstein lab also collaborated with Pawel Osmulski,
Ph.D., assistant professor of molecular medicine; Susan Weintraub,
Ph.D., professor of biochemistry; and Maria Gaczynska, Ph.D.,
associate professor of molecular medicine.
Naked mole rats, which burrow through underground tunnels in their
native East Africa, are nearly hairless rodents. They live as long
as 32 years. Naked mole rats maintain cancer-free good health and
reproductive potential well into their third decade of life.
This finding is in the journal BBA: Molecular Basis of Disease.
Biochim Biophys Acta 2014 Jul 10. Epub 2014 Jul 10.
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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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