[GRG] gene needed for de-differentiating back to a stem cell identified

a gene that determines whether a specialized cell conserves the
capacity to become a stem cell again

Specification of Differentiated Adult Progenitors via Inhibition of
Endocycle Entry in the Drosophila Trachea

DOI: http://ift.tt/1wFIznZ

Highlights

•Fzr regulates cell-cycle mode and progenitor potential in the
Drosophila trachea
•Homeotic genes specify a set of differentiated tracheal cells as
adult progenitors
•Hormonal signaling through Ecdysone activates differentiated
tracheal progenitors

Summary

A population of Drosophila adult tracheal progenitor cells arises
from differentiated cells of the larval main trachea that retain
the ability to reenter the cell cycle and give rise to the multiple
adult tracheal cell types. These progenitors are unique to the
second tracheal metamere as homologous cells from other segments,
express fizzy-related (fzr), the Drosophila homolog of CDH1 protein
of the APC complex, and enter endocycle and do not contribute to
adult trachea. Here, we examine the mechanisms for their quiescence
and show that they reenter the cell cycle by expression of
string/cdc25 through ecdysone. Furthermore, we show that preventing
endocycle entry is both necessary and sufficient for these tracheal
cells to exhibit markers of adult progenitors, thus modifying their
genetic program. Finally, we show that Hox-mediated regulation of
fzr expression is responsible for progenitor identity and thus
specifies a group of differentiated cells with facultative stem
cell features.

This is an open access article under the CC BY-NC-ND license
(http://ift.tt/fzkL8X).

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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