[GRG] High-intensity sound waves may aid regenerative medicine

High-intensity sound waves may aid regenerative medicine


October 30, 2014


Acoustical Society of America (ASA)


Researchers have developed a way to use sound to create cellular
scaffolding for tissue engineering, a unique approach that could
help overcome one of regenerative medicine’s significant obstacles.

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This is a cross section through a histotripsy lesion created in
bovine liver tissue with the liquified cellular contents washed out
revealing the remaining extracellular matrix. The scale bar
represents 5mm.

Credit: T.Khoklova/UW

[Click to enlarge image]

Researchers at the University of Washington have developed a way to
use sound to create cellular scaffolding for tissue engineering, a
unique approach that could help overcome one of regenerative
medicine’s significant obstacles. The researchers will present
their technique at the 168th meeting of the Acoustical Society of
America (ASA), held October 27-31, 2014, at the Indianapolis
Marriott Downtown Hotel.

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The development of the new technique started with somewhat of a
serendipitous discovery. The University of Washington team had been
studying boiling histotripsy — a technique that uses millisecond-
long bursts of high-intensity ultrasound waves to break apart
tissue — as a method to eliminate cancerous tumors by liquefying
them with ultrasound waves. After the sound waves destroy the
tumors, the body should eliminate them as cellular waste. When the
researchers examined these ‘decellularized’ tissues, however, they
were surprised by what the boiling left intact.

“In some of our experiments, we discovered that some of the stromal
tissue and vasculature was being left behind,” said Yak-Nam Wang, a
senior engineer at the University of Washington’s Applied Physics
Laboratory. “So we had the idea about using this to decellularize
tissues for tissue engineering and regenerative medicine.”

The structure that remains after decellularizing tissues is known
as the extracellular matrix, a fibrous network that provides a
scaffold for cells to grow upon. Most other methods for
decellularizing tissues and organs involve chemical and enzymatic
treatments that can cause damage to the tissues and fibers and
takes multiple days. Histrostipsy, on the other hand, offers the
possibility of fast decellularization of tissue with minimal damage
to the matrix.

“In tissue engineering, one of the holy grails is to develop
biomimetic structures so that you can replace tissues with native
tissue,” Wang said. Stripping away cells from already developed
tissue could provide a good candidate for these structures, since
the extracellular matrix already acts as the cellular framework for
tissue systems, Wang said.

Due to its bare composition, the matrix also induces only a
relatively weak immune response from the host. The matrix could
then theoretically be fed with stem cells or cells from the same
person to effectively re-grow an organ.

“The other thought is that maybe you could just implant the
extracellular matrix and then the body itself would self-seed the
tissues, if it’s just a small patch of tissue that you’re
replacing,” Wang said. “You won’t have any immune issues, and
because you have this biomimetic scaffold that’s closer to the
native tissue, healing would be better, and the body would
recognize it as normal tissue.”

Wang is currently investigating decellularization of kidney and
liver tissue from large animals. Future work involves increasing
the size of the decellularized tissues and assessing their in-vivo
regenerative efficacy.

Story Source:

The above story is based on materials provided by Acoustical
Society of America (ASA). Note: Materials may be edited for content
and length.

Cite This Page:


Acoustical Society of America (ASA). “High-intensity sound waves
may aid regenerative medicine.” ScienceDaily. ScienceDaily, 30
October 2014.
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About Johnny Adams

My full-time commitment is to slow and ultimately reverse biological aging and age related decline for more years of healthy living. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Aging Intervention Foundation (dba for Carl I. Bourhenne Medical Research Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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