[GRG] Naturally occurring molecule may prevent atherosclerosis


Naturally occurring molecule may prevent atherosclerosis


July 11, 2012


Cleveland Clinic


Researchers have discovered that a naturally occurring molecule may
play a role in preventing plaque buildup inside arteries, possibly
leading to new plaque-fighting drugs and improved screening of
patients at risk of developing atherosclerosis

Cleveland Clinic researchers have discovered that a naturally
occurring molecule may play a role in preventing plaque buildup
inside arteries, possibly leading to new plaque-fighting drugs and
improved screening of patients at risk of developing

Sometimes called hardening or clogging of the arteries,
atherosclerosis is the buildup of cholesterol, fatty cells, and
inflammatory deposits on the inner walls of the arteries,
restricting blood flow to the heart. The disease can affect the
arteries in the heart, legs, brain, kidneys, and other organs, and
is the most common cause heart attacks, strokes, and peripheral
vascular disease.

At the cellular level, plaque buildup is the result of macrophages
in the vessel wall absorbing, processing, and storing cholesterol
(lipids) and then accumulating in large amounts, eventually leading
to the development of arterial lesions. The researchers, led by
Eugene Podrez, M.D., Ph.D., of the Department of Molecular
Cardiology at Cleveland Clinic’s Lerner Research Institute, have
discovered that the naturally occurring molecule Akt3 regulates
lipid entry into macrophages and prevents the cells from storing
excessive amounts of cholesterol and collecting in the artery.

Podrez says the discovery could lead to new drugs designed to
prevent atherosclerosis. It could also help doctors develop
screening tests to determine patient risk level for developing the
disease. Podrez and his colleagues are now looking into the
particular mechanisms behind Akt3’s role in regulating lipid
processing and will attempt to replicate their results in humans.

Story Source:

The above story is based on materials provided by Cleveland Clinic.
Note: Materials may be edited for content and length.

Journal Reference:
1.Liang Ding, Sudipta Biswas, Richard E. Morton, Jonathan D. Smith,
Nissim Hay, Tatiana V. Byzova, Maria Febbraio, Eugene A. Podrez.
Akt3 Deficiency in Macrophages Promotes Foam Cell Formation and
Atherosclerosis in Mice. Cell Metabolism, 2012; 15 (6): 861 DOI:

Sent using Hushmail


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
This entry was posted in Uncategorized. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s