[GRG] NewAbs: A Key To Forming New Muscle Stem Cells — Sarcopenia

Good pickup on  Sunday… — Steve Coles
At 12:34 PM 9/7/2014, you wrote:

http://ift.tt/Wv61GX: Deborah Robison
drobison@sanfordburnham.org
858-646-3146
Sanford-Burnham Medical Research Institute
“Researchers Discover a Key
to Making New Muscles”
    A new study finds that cyclic bursts of a STAT3
inhibitor can
replenish muscle stem cells and promote their differentiation into
muscle fibers. The findings are an important step toward developing
and maintaining new muscle to treat muscle diseases.  IMAGE: This image depicts normal muscle (left) and muscle from
Muscular Dystrophy (right).
Click here for more information.
September 7, 2014; La Jolla, CA (Sanford-Burnham) — Researches
at Sanford-BurnhamnMedical Research Institute have developed a
novel technique to promote tissue repair in damaged muscles. The
technique also creates a sustainable pool of muscle stem cells
needed to support multiple rounds of muscle repair. The study,
published September 7th in Nature Medicine, provides promise for

a new therapeutic approach to treating the millions of people
suffering from muscle diseases, including those with muscular
dystrophies and muscle wasting associated with cancer and aging.

    There are two important processes that need to happen
to maintain
skeletal-muscle health. First, when muscle is damaged by injury or
degenerative disease such as muscular dystrophy, muscle stem
cells — or satellite cells — need to differentiate into mature muscle

cells to repair injured muscles. Second, the pool of satellite
cells needs to be replenished so there is a supply to repair muscle
in case of future injuries. In the case of muscular dystrophy, the
chronic cycles of muscle regeneration and degeneration that involve
satellite-cell activation exhaust the muscle stem-cell pool to the
point of no return.
    “Our study found that by introducing an inhibitor
of the STAT3
protein in repeated cycles, we could alternately replenish the pool
of satellite cells and promote their differentiation into muscle
fibers,” said Alessandra Sacco, Ph.D., Assistant Professor in the

Development, Aging, and Regeneration Program at Sanford-Burnham.
“Our results are important because the process works in mice and in

human muscle cells.”
    “Our next step is to see how long we can extend
the cycling
pattern, and test some of the STAT3 inhibitors currently in
clinical trials for other indications such as cancer, as this could
accelerate testing in humans,” added Sacco.
    “These findings are very encouraging. Currently,
there is no cure
to stop or reverse any form of muscle-wasting disorders — only
medication and therapy that can slow the process,” said Vittorio

Sartorelli, M.D., Chief of the Laboratory of Muscle Stem Cells and
Gene Regulation and Deputy Scientific Director at the National
Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS). “A treatment approach consisting of cyclic bursts of
STAT3 inhibitors could potentially restore muscle mass and function
in patients, and this would be a very significant breakthrough.”
Revealing the mechanism of STAT3
   STAT3 (signal transducer and activator of transcription 3)
is a
protein that activates the transcription of genes in response to IL-6,

a signaling protein released by cells in response to injury and
inflammation. Prior to the study, scientists knew that STAT3 played
a complex role in skeletal muscle, promoting tissue repair in some
instances and hindering it in others. But the precise mechanism of
how STAT3 worked was a mystery.
    The research team first used normally aged mice and
mice models of
a form of muscular dystrophy that resembles the human disease to
see what would happen if they were given a drug to inhibit STAT3.
They found that the inhibitor initially promoted satellite-cell
replication,
followed by differentiation of the satellite cells into muscle fibers.

When they injected the STAT3 inhibitor every seven days for 28 days,
they found an overall improvement in skeletal-muscle repair, and an
increase in the size of muscle fibers.
    “We were pleased to find that we achieved similar
results when we
performed the experiments in human muscle cells,” said Sacco.
“We
have discovered that by timing the inhibition of STAT3 — like an
“on/off” light switch — we can transiently expand the
satellite-cell
population followed by their differentiation into mature muscle
cells.”

L. Stephen Coles, M.D., Ph.D., Cofounder
Los Angeles Gerontology Research GroupE-mail: scoles@grg.orgE-mail:
scoles@ucla.edu

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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