[GRG] NewAbs: Biological Clock Synchronization

To Members and Friends of the Los Angeles Gerontology
Research Group:
        Biological clock
synchronization with Alpha Lipoic Acid (ALA).  See Abstract
below..  — Steve Coles

“Lipoic Acid Helps Restore,
Synchronize the “Biological Clock”

by
David Stauth, Oregon State UniversityFriday, July 18 2014; (R&D) — Researchers
have discovered a possible explanation for the surprisingly large range
of biological effects that are linked to a micronutrient called lipoic
acid: It appears to reset and synchronize circadian rhythms, or the
“biological clock” found in most life forms.
    The ability of lipoic acid to help restore a more
normal circadian rhythm to aging animals could explain its apparent value
in so many important biological functions, ranging from stress resistance
to cardiac function, hormonal balance, muscle performance, glucose
metabolism, and the aging process.
    The findings were made by biochemists from the Linus
Pauling Institute at Oregon State University, and published in
Biochemical and Biophysical Research Communications. The research
was supported by the National Institutes of Health, through the National
Center for Complementary and Alternative Medicine (CAM).
    Lipoic acid has been the focus in recent years of
increasing research by scientists around the world, who continue to find
previously unknown effects of this micronutrient. As an antioxidant and
compound essential for aerobic metabolism, it’s found at higher levels in
organ meats and leafy vegetables, such as spinach and broccoli.
    “This could be a breakthrough in our understanding of
why lipoic acid is so important and how it functions,” said Tory Hagen,
the Helen P. Rumbel Professor for Healthy Aging Research in the Linus
Pauling Institute, and a Professor ofBiochemistry and Biophysics in the
OSU College of Science.  “Circadian rhythms are day-night cycles
that affect the daily ebb and flow of critical biological processes,”
Hagen said. “The more we improve our understanding of them, the more we
find them involved in so many aspects of life.” “Almost one-third of
all genes are influenced by circadian rhythms, and when out of balance
they can play roles in cancer, heart disease, inflammation, hormonal
imbalance, and many other areas,” the OSU researchers said.
    Of particular importance is the dysfunction of
circadian rhythms with age.  “In old animals, including elderly
humans, it’s well-known that circadian rhythms break down and certain
enzymes don’t function as efficiently, or as well as they should,” said
Dove Keith, a Research Associate in the Linus Pauling Institute and lead
author on this study.  “This is very important, and probably
deserves a great deal more study than it is getting,” Keith said. “If
lipoic acid offers a way to help synchronize and restore circadian
rhythms, it could be quite significant.”
    In this case the scientists studied the “circadian
clock” of the liver. Lipid metabolism by the liver is relevant to normal
energy use, metabolism, and when dysfunctional can help contribute to the
“metabolic syndrome” that puts millions of people at higher risk of heart
disease, diabetes, and cancer.
    Researchers fed laboratory animals higher levels of
lipoic acid than might be attained in a normal diet, while monitoring
proteins known to be affected by disruption of the circadian clock in
older animals.  They found that lipoic acid helped remediate some of
the liver dysfunction that’s often common in old age, and significantly
improved the function of their circadian rhythms.  In previous
research, scientists found that the amount of lipoic acid that could aid
liver and normal lipid function was the equivalent of about 600 mg qd for
a 150-pound human, more than could normally be obtained through the
diet.
    A primary goal of research in the Linus Pauling
Institute and the OSU Center for Healthy Aging Research is to promote
what scientists call “healthspan” – not just the ability to live a long
life, but to have comparatively good health and normal activities during
almost all of one’s life. Research on lipoic acid, at OSU and elsewhere,
suggests it has value toward that goal.  Continued research will
explore this process and its role in circadian function, whether it can
be sustained, and optimal intake levels that might be needed to improve
health.Source:

Oregon State Univ.
Topics:

R &
D Daily

Biology

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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