[GRG] NewAbs: Spns-1 Gene Controls the Rate of Aging

More later… — Steve Coles

“Newfound Gene Could Play a Role in
Aging from Birth”
Courtesy of the Scripps Research Institute and
World Science staff
Tuesday, July 17, 2014; (World Science) —  It’s something of
an eternal question: Can we slow or even reverse aging? Although genetic
manipulations can alter some cellular processes, not so much is known
about the mechanisms of the aging process in living things.Now
scientists have found in animal models that one gene plays a surprising
role in aging that can be detected early on in development. They say the
discovery could point toward the possibil­ity of one day us­ing
ther­a­peu­tics, even some com­monly used ones, to manipulate the aging
process itself.This
“developmental gene, known as Spns-1, may mediate the aging process,”
said Shuji Kishi, a Professor at the from the Florida campus of The
Scripps Research Institute who led the study, published by the journal
PLoS Ge­net­ics. “Even a partial loss of Spns-1 function can speed
aging.”Using
various genetic approaches to disturb Sp­ns1 during the embryonic and/or
larval stages of zebrafish -­ which have emerged as useful for studying
diseases associated with development and aging -­ the scientists said
they produced some models with a shortened lifespan, others that lived
long lives.While most
studies of “senescence” ­- decreases in a cell’s power of division and
growth ­- have focused on later stages of life, the new study explores
early stages. “Mutations to Spns-1 both disturbs developmental senescence
and badly affects the long-term biochronological aging process,” Kishi
said.The study
found that Spns-1, along with a pair of “tumor suppressor genes,” called
beclin-1 and p53, can influence senescence through two
different mechanisms: the Spns-1 defect was enhanced by Beclin-1 but
suppressed by ‘basal’ p53. Spns1 also was found to hinder autophagy, a
process whereby cells remove unwanted or destructive proteins and balance
energy needs during various life stages.Building
on their insights from the study, Kishi and his colleagues noted in the
future therapeutics might be able influence aging through Spns-1. He said
a commonly used antacid, Prilosec, has been shown to temporarily suppress
autophagic abnormality and senescence seen in the Spns-1
deficiency.

L. Stephen Coles, M.D., Ph.D., Cofounder
Los Angeles Gerontology Research GroupE-mail: scoles@grg.orgE-mail:
scoles@ucla.edu

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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