[GRG] Salamander skin peptide promotes quick healing in mice

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Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Salamander skin peptide promotes quick and effective wound healing
in mice
New research in The FASEB Journal suggests that a short peptide
called tylotoin exerts the promotion of wound healing with
epidermal growth factor (EGF) in a murine model of a full thickness
dermal wound
Move over antibiotic ointment, there might be a new salve to
dominate medicine cabinets of the future, and it comes from an
unlikely place—the lowly salamander. Salamanders may not be the
cuddliest of animals, but they can regenerate lost limbs and
achieve amazing recovery of seriously damaged body parts. Now, a
new report published in the September 2014 issue of The FASEB
Journal, identifies a small protein (called a “peptide”) from the
skin of salamanders that may be the key to unlocking the secret of
this amazing wound healing trick in humans.
“This research takes a step toward an understanding of the cellular
and molecular events that underlie quick wound healing in the
salamander by the discovery of a potential wound healing promoting
peptide,” said Ren Lai, Ph.D., a researcher involved in the work
from the Kunming Institute of Zoology at the Chinese Academy of
Sciences in Yunnan, China.
To make this discovery, Lai and colleagues collected skin extract
from salamanders and separated it by gel filtration and high
performance liquid chromatography. The skin component from
salamanders was subjected to keratinocyte cell proliferation and
endothelial cell tube formation assay to evaluate possible wound
healing potential. This component was further subjected to
structure and functional analysis, which pointed toward a short
peptide called tylotoin that contained 12 amino acid residues. This
peptide was found to exert the ability to promote wound healing
with epidermal growth factor (EGF) in a murine model of a full
thickness dermal wound. Tylotoin directly enhances the motility and
proliferation of keratinocytes, vascular endothelial cells and
fibroblasts, resulting in accelerated re-epithelialization and
granulation tissue formation in the wound site. Tylotoin also
promotes the release of transforming growth factor beta1 and
interleukin 6, which are essential in the wound healing response.
“Until now, rapid wound healing has been the stuff of superheroes
and science fiction,” said Gerald Weissmann, M.D., Editor-in-Chief
of The FASEB Journal. “Scientists have always wondered how some
‘lower’ animals heal wounds that would be mortal to humans. Now, we
are taking concrete steps to mimic this ancient – and forgotten –
healing process in our own bodies.”
###
Receive monthly highlights from The FASEB Journal by e-mail. Sign
up at http://ift.tt/1A2ru7p. The FASEB Journal is
published by the Federation of the American Societies for
Experimental Biology (FASEB). It is the world’s most cited biology
journal according to the Institute for Scientific Information and
has been recognized by the Special Libraries Association as one of
the top 100 most influential biomedical journals of the past
century.
FASEB is composed of 27 societies with more than 120,000 members,
making it the largest coalition of biomedical research associations
in the United States. Our mission is to advance health and welfare
by promoting progress and education in biological and biomedical
sciences through service to our member societies and collaborative
advocacy.
Details: Lixian Mu, Jing Tang, Han Liu, Chuanbin Shen, Mingqiang
Rong, Zhiye Zhang, and Ren Lai. A potential wound-healing-promoting
peptide from salamander skin. FASEB J. September 2014 28:3919-3929;
doi:10.1096/fj.13-248476 ;
http://ift.tt/1A2ru7r

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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