[GRG] Stem cells aid muscle repair and strengthening after resistance exercise

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Stem cells aid muscle repair and strengthening after resistance
exercise

Marni Boppart

Photo by
L. Brian Stauffer

University of Illinois kinesiology and community health professor
Marni Boppart studies the mechanisms that enable muscles to recover
and grow stronger after exercise.

7/21/2014 | Diana Yates, Life Sciences Editor | 217-333-5802;
diya@illinois.edu

CHAMPAIGN, Ill. — A new study in mice reveals that mesenchymal
(mezz-EN-chem-uhl) stem cells (MSCs) help rejuvenate skeletal
muscle after resistance exercise.

By injecting MSCs into mouse leg muscles prior to several bouts of
eccentric exercise (similar to the lengthening contractions
performed during resistance training in humans that result in mild
muscle damage), researchers were able to increase the rate of
repair and enhance the growth and strength of those muscles in the
exercising mice.

The findings, described in the journal Medicine and Science in
Sports and Exercise, may one day lead to new interventions to
combat age-related declines in muscle structure and function, said
University of Illinois kinesiology and community health professor
Marni Boppart, who led the research.

“We have an interest in understanding how muscle responds to
exercise, and which cellular components contribute to the increase
in repair and growth with exercise,” she said. “But the primary
goal of our lab really is to have some understanding of how we can
rejuvenate the aged muscle to prevent the physical disability that
occurs with age, and to increase quality of life in general as
well.”

MSCs occur naturally in the body and may differentiate into several
different cell types. They form part of the stroma, the connective
tissue that supports organs and other tissues.

MSCs also excrete growth factors and, according to the new study,
stimulate muscle precursor cells, called satellite cells, to expand
inside the tissue and contribute to repair following injury. Once
present and activated, satellite cells actually fuse to the damaged
muscle fibers and form new fibers to reconstruct the muscle and
enhance strength.

“Satellite cells are a primary target for the rejuvenation of aged
muscle, since activation becomes increasingly impaired and recovery
from injury is delayed over the lifespan,” Boppart said. “MSC
transplantation may provide a viable solution to reawaken the aged
satellite cell.”

Satellite cells themselves will likely never be used
therapeutically to enhance repair or strength in young or aged
muscle “because they cause an immune response and rejection within
the tissue,” Boppart said. But MSCs are “immunoprivileged,” meaning
that they can be transplanted from one individual to another
without sparking an immune response.

“Skeletal muscle is a very complex organ that is highly innervated
and vascularized, and unfortunately all of these different tissues
become dysfunctional with age,” Boppart said. “Therefore,
development of an intervention that can heal multiple tissues is
ideally required to reverse age-related declines in muscle mass and
function. MSCs, because of their ability to repair a variety of
different tissue types, are perfectly suited for this task.”

The Ellison Medical Foundation and the National Science Foundation
supported this work.

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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