[GRG] Video: Precision Medicine for Cancer

To Members and Friends of the Los Angeles Gerontology
Research Group:  Although
it’s sort of like an advertisement, CTCA produced a cool video  with
animation that I fully agree with…
http://ift.tt/1jLnkyt(TRT = 3:44 min.) — Steve Coles

“Genomic Tumor

Treatment Centers of America® (CTCA) now offers expanded genomic tumor
assessment that may identify cancer treatment options not previously
tumor assessment reveals the DNA alterations that are driving the growth
of a cancer. As we understand more about these gene mutations, we are
better able to provide cancer treatment therapies that specifically
target changes in the tumor’s genomic profile. Your oncologist will help
determine if you are a good candidate for genomic testing.

Treating cancer

Precision medicine

Genomic testing


The Evolution of Cancer Care
For more
than 100 years, scientists have been searching for better ways to treat
cancer. The development of radiation therapy in the early 1900’s and
chemotherapy in the 1940’s were two milestones. But both had significant
chemotherapy drugs lacked the selective capacity to distinguish between
cancer cells and normal cells, resulting in toxic and sometimes
intolerable side effects for patients. Radiation therapy initially was
shown to cause cancer in addition to treating it.Both
therapies have become more targeted thanks to advances in medicine, and
researchers have found ways to minimize side effects. Today,

radiation therapy and

chemotherapy are considered the standard of care in treating cancer
patients and millions of survivors have lived longer as a
result.But these
therapies still have limitations. For example, two patients displaying
symptoms and imaging results associated with a certain cancer might be
prescribed the same chemotherapy regimen and experience drastically
different outcomes. Why? Because the root cause of their disease and the
treatment needed are different.
Researchers have been studying the root cause of disease since the
Human Genome Project, completed a
decade ago, opened up a whole new world of inquiry. After 13 years,
researchers mapped the entire human genetic code. They found that every
human is comprised of about 20,500 genes. Using this information,
researchers have linked dozens of diseases such as Alzheimer’s Disease
and inherited colon cancer to specific genes.In the
case of cancer, researchers have discovered that two genes, BRCA-1 and
BRCA-2, are associated with

breast and

ovarian cancers. Likewise, researchers have developed a drug
specifically to treat breast cancers showing an overproduction of the
protein HER-2.Those
innovations, now standard, target genetic abnormalities inherited through
a family line. In recent years, researchers have been looking at genetic
mutations that have nothing to do with heredity. They have zeroed in on
genomic abnormalities that occur within the disease itself. Genomic
testing for cancer, in particular, looks at an individual patient’s tumor
to match genetic abnormalities to a drug therapy.
Bringing Precision Medicine to the
cancer is different. Genomic testing helps our doctors understand a
patient’s cancer at the molecular level. Information about genomic
changes that are unique to your individual cancer will help us determine
treatments most likely to work for you. It’s the promise of precision
cancer treatment -­ a focus on the individual tumor in the individual
L. Stephen Coles, M.D., Ph.D., Cofounder
Los Angeles Gerontology Research GroupE-mail: scoles@grg.orgE-mail:


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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