Re: [GRG] Aspirin, Metformin: first two human geroprotectors with high credential

As they say, don’t trust anybody and then verify. 

Mr. Debonneuil quotes (albeit disbelievingly) Mr. Rae who (very confidently) quotes a meta-analysis by Dr Bartolucci et al, (PMID 21481826) who read a bunch of articles and came to the conclusion that all-cause mortality effects of low-dose aspirin are null.

Yours truly is non-plussed, having heard an aspirin a day keeps the doctor away.

A bit later however, Dr Bartolucci publishes an erratum:

“The conclusion concerning “All cause mortality” in the paper was incorrect. There is a statistically significant advantage for aspirin in reducing the risk. In Table 3 the odds ratio should be 0.934 with 95% Confidence Interval (0.874, 0.999) and p-value for treatment favoring aspirin, p = 0.0.045. This information also applies to Figure 3 with z-value = −2.004. The p-value for Heterogeneity in Table 3 is 0.989. The reported result was due to incorrect data input for the AAT and POPADAD studies, In Figure 3 the correct odds ratio for AAT is 0.940 with lower 95% confidence limit = 0.756 and upper limit = 1.169, z-value = −0.556 and p-value = 0.578. Likewise for the POPADAD study the correct odds ratio is 0.919 with lower limit = 0.677 and upper limit = 1.247, z-value = −0.545 and p-value = 0.586.”Gee-whiz, who could have guessed? You write an article whose main claim is aspirin does not save net lives, you even get it published, and, oops, you are forced to eat your words and say the opposite in an erratum. To make it even more painful, a Dr Sutcliffe (PMID 24074752 ), in another similar meta-analysis, shows that, yes, aspirin saves net lives in primary prevention.

It is hard to escape the impression that aspirin is good for you.

RafalOn Tue, Aug 12, 2014 at 2:07 AM, Edouard Debonneuil wrote:>


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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