Re: [GRG] Aspirin, Metformin: first two human geroprotectors with high credential

Hello, please find a further response (that did not go through) from Michael Rae:

“All,

On aspirin, please see:http://ift.tt/1vAVjyT… and references.On
metformin in Edouard’s message below: please refer to the linked post, not only the extract quoted below.See also, in normal, healthy mice (unlike all the Anisimov  studies, eg):http://ift.tt/VeA05I”

De : Edouard Debonneuil À : Gerontology Research Group Cc : Avi Roy ; “mikalra@cadvision.com” Envoyé le : Lundi 11 août 2014 23h20Objet : Re: [GRG] Aspirin, Metformin: first two human geroprotectors with high credential

Here is the answer from Michael Rae (empirically I understand it is Ok to transfer):

http://ift.tt/1sRKlR1 indicated, I haven’t read the actual paper myself: I’m going off of the abstract and this statistics prof’s summary. Based on that, I
don’t think there’s any way to productively mine this specific report.If you really wanted an answer, you’d need a large linked health registry analysis lke the ones that many Nordic countries have and of which the UK has at least one, in which all members of a
large cohort are systematically tracked for health outcomes over time, to get actual life expectancy data combined with unbiased medication use records.However, at this point the rodent data suggest to me that this is not a productive use of anyone’s time or
research budget. Metformin is a healthier drug than any other if you have diabetes or metabolic syndrome; there’s no real reason to think it’s of any use to normoglycemics, or even that it’s
better in prediaabetes than diet and exercise.It is also pretty well-established that aspirin does not lower total mortality in people without previous MI or stroke, despite
its apparent benefit in reducing colon and possibly some other cancer incidence rates, particularly in susceptible populations.

Myself, I am surprised
to conclude so rapidly, but empirically Michael is right even when it surprises 😉 so I am planning to look at the two papers [1][2] in details before saying anything more about the topic (at least I will improve specific understandings on the nuances that make all the difference) and would be happy if a few others want to do the same :

[1] Estimates of benefits and harms of prophylactic use of aspirin in the general population. http://ift.tt/1kR7tiB

[2] Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls http://ift.tt/V70XrO

Cheers,

Edouard

De : Gwern Branwen À : Gerontology Research Group Envoyé le
: Lundi 11 août 2014 20h44Objet : Re: [GRG] Aspirin, Metformin: first two human geroprotectors with high credential

On Sun, Aug 10, 2014 at 12:17 PM, Allen Taylor wrote:> This research has been trashed pretty
convincingly by Michael Rae on the> calorie restriction list. The
essence of his critique is that all the really> sick diabetics were “censored” (i.e. removed) from the study as soon as> their disease progressed to the point where they were given a second drug.Could you provide a link or copy? I’m not sure I’ve heard of thatmailing list before, and some
searches for ‘metformin Michael Raecalorie restriction list censored’ and variants doesn’t seem to turnup
anything useful.– gwernhttp://www.gwern.net

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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