I was just curious to see if there was a particular period over the past decades which was most productive of LE leads. For example, has increasing research a decade ago increased the
number of new compounds found to increase LE. Or, conversely, has the decrease in Government funding over the past 8 years decreased the number of compounds found?
Interestingly, after CombiChem & High throughput biological screening was adopted by Pharma & Ag companies as standard operating procedures (say, about 25 years ago) instead of a dramatic increase in NCE’s
(New Chemical Entities) approved for marketing by the FDA, they dropped dramatically from the 50-60/year range down to the 20’s/ year. Only last year did the NCE list go back up to the low 30’s/year.
This was & remains a difficult mystery to explain.
What I’m trying to get at is what research practices lead to more discoveries of quality lead LE & HS compounds? Do your tables record papers reporting increased healthspan?
On Jun 6, 2014, at 9:19 PM, email@example.com wrote:
> If I understand Elliot correctly, he was
> interested in something like the attached graph.
> I hope you like it.