Given that, before humans, the mortality reduction of low dose long term aspirin was first found in mice,
>> “Low dose aspirin, of course, cannot be viewed in the same light as full dose ibuprofen or naproxen.”
it would be interesting to test low dose ibuprofen in mice
at low dose it might be the anti-platelet aggregation effect of aspirin that mostly leads to benefits, although we don’t know. A subtle and unnoticed effect, repeated over time, could lead to a major effect / positive adaptation of the body
>> “Low dose aspirin people might consider gastric acid blockade with H2 blockers or proton pump inhibitors, or the like.”
unless it wouldn’t make sense with the mouse physiology (?), it seems to me such things should be tested in mice as well. In case for instance mild gastric acidification leads to long term health benefits 🙂
Of course, if testing in humans was not so complex and uncertain, we should forget about the mice.
De : sbharris1 À : Gerontology Research Group Envoyé le : Samedi 20 décembre 2014 1h52Objet : Re: [GRG] Does Ibuprofen slow the aging process?
It is damaging to the GI tract.
NSAIDs like ibuprofen and naproxin kill
at least 3,000 people a year from GI bleeding in the US alone, and nonfatal
hospitalizations from GI bleed may be as large as 100,000 per year.
This doesn’t count the excess deaths
from heart attack, as full-dose NSAIDs have a pro-MI role, and increase your
chance of MI by around 40%, and this increase lasts at least 5 years, and
probably as long as you take them. That 40% may not sound like much, but
it’s as much as statins DECREASE MIs, in most studies.
If you take the number of people who
die of MI each year, an increase of 40% would be a staggering number.
Fortunately, not all people who have had an MI, or are at risk for one, are on
I suggest staying away from these
drugs, for the long term. Certainly don’t take them over the counter, hoping
you’ll age more slowly like some yeast cell. These are short-term
drugs only, except in very special circumstances (your doc will give you the
argument for long term, if you take them under a doctor’s
Low dose aspirin, of course, cannot be
viewed in the same light as full dose ibuprofen or naproxen. Low dose aspirin
(81 to 325 mg per day) has very little anti-inflammatory effect, although it
does increase risk of GI bleed (not as much). Low dose aspirin people might
consider gastric acid blockade with H2 blockers or proton pump inhibitors, or