Re: [GRG] Does Ibuprofen slow the aging process?

Given that, before humans, the mortality reduction of low dose long term aspirin was first found in mice,

>> “Low dose aspirin, of course, cannot be viewed in the same light as full dose ibuprofen or naproxen.”

it would be interesting to test low dose ibuprofen in mice

at low dose it might be the anti-platelet aggregation effect of aspirin that mostly leads to benefits, although we don’t know. A subtle and unnoticed effect, repeated over time, could lead to a major effect / positive adaptation of the body

>> “Low dose aspirin people might consider gastric acid blockade with H2 blockers or proton pump inhibitors, or the like.”

unless it wouldn’t make sense with the mouse physiology (?), it seems to me such things should be tested in mice as well. In case for instance mild gastric acidification leads to long term health benefits 🙂

Of course, if testing in humans was not so complex and uncertain, we should forget about the mice.

Cheers,

Edouard

De : sbharris1 À : Gerontology Research Group Envoyé le : Samedi 20 décembre 2014 1h52Objet : Re: [GRG] Does Ibuprofen slow the aging process?

It is damaging to the GI tract.

 

NSAIDs like ibuprofen and naproxin kill
at least 3,000 people a year from GI bleeding in the US alone, and nonfatal
hospitalizations from GI bleed may be as large as 100,000 per year.

 

This doesn’t count the excess deaths
from heart attack, as full-dose NSAIDs have a pro-MI role, and increase your
chance of MI by around 40%, and this increase lasts at least 5 years, and
probably as long as you take them. That 40% may not sound like much, but
it’s as much as statins DECREASE MIs, in most studies.

 

http://ift.tt/1wwwxiE

 

If you take the number of people who
die of MI each year, an increase of 40% would be a staggering number.
Fortunately, not all people who have had an MI, or are at risk for one, are on
NSAIDs.

 

I suggest staying away from these
drugs, for the long term. Certainly don’t take them over the counter, hoping
you’ll age more slowly like some yeast cell. These are short-term
drugs only, except in very special circumstances (your doc will give you the
argument for long term, if you take them under a doctor’s
care).  

 

Low dose aspirin, of course, cannot be
viewed in the same light as full dose ibuprofen or naproxen. Low dose aspirin
(81 to 325 mg per day) has very little anti-inflammatory effect, although it
does increase risk of GI bleed (not as much). Low dose aspirin people might
consider gastric acid blockade with H2 blockers or proton pump inhibitors, or
the like.

 

Steve Harris

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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