On Fri, Dec 19, 2014 at 7:52 PM, sbharris1 wrote:
Low dose aspirin, of course, cannot be
viewed in the same light as full dose ibuprofen or naproxen. Low dose aspirin
(81 to 325 mg per day) has very little anti-inflammatory effect, although it
does increase risk of GI bleed (not as much). Low dose aspirin people might
consider gastric acid blockade with H2 blockers or proton pump inhibitors, or
### I agree with you, people should definitely stay away from full-dose NSAIDS, use only if you really can’t do without, stop as soon as you can, be aware of the renal, hepatic, cardiovascular and GI toxicity. Yes, low-dose ASA is another story, and the preponderance of evidence is in favor a 6% reduction in all-cause mortality in primary prevention in middle-aged men.
I wouldn’t use H2 blockers or PPIs with low-dose ASA, though. The GI effects of 81 mg ASA are minimal, you should take it with food, even if you combine it with other drugs that may be good for you but can be harsh on the stomach (metformin, donepezil) you shouldn’t expect too much trouble, and if you do, get evaluated by a GI specialist before considering OOC H2 or PPI – these medications also have their side-effects and should not be used just in case.