On Sat, Dec 20, 2014 at 3:28 AM, Edouard Debonneuil wrote:
>> “Low dose aspirin people might consider gastric acid blockade with H2 blockers or proton pump inhibitors, or the like.”
unless it wouldn’t make sense with the mouse physiology (?), it seems to me such things should be tested in mice as well. In case for instance mild gastric acidification leads to long term health benefits 🙂
### AFAIK, ASA does not cause gastric acidification. It decreases activity of cyclooxygenase, which in turn leads to deficiency of prostaglandins that are key stimulators of cytoprotective mechanisms in the gastric mucosa, including production of mucus and secretion of bicarbonate. The net effect is increased susceptibility to existing acid, not more acid.
Of course, if testing in humans was not so complex and uncertain, we should forget about the mice.
### Effects in mice should be seen as inspiration for more research, including animal studies in other species, but they should not be used to justify any routine use of drugs. Well-controlled human studies, however complex, are an absolute precondition for wide-spread human drug use, especially in chronic conditions, such as aging.