Stan and I are delighted to receive this news!
We appreciate all you do for so many of us!
Enjoy New York City!
Sending love and caring thoughts,
On Jun 20, 2014, at 2:30 PM, Robert Young wrote:
Dr. Coles called me this afternoon and asked me to inform the Gerontology Research Group that, after the latest round of chemotherapy, the tumors in his liver and pancreas have shown signs of remission/shrinkage. They are not gone but this is the first report where they were smaller than the previous test.
Dr. Coles is planning to take a trip to New York June 22-28, 2014 and will be mostly unavailable.
Dr. Coles will begin his next round of chemotherapy on July 1, 2014.
This battle is not over…Dr. Coles is fighting to come back and defeat the cancer. Thanks to everyone who has helped by donating to Dr. Cole’s cancer treatment fund and may you continue to do so if able.
Senior Database Administrator
From: Rafal Smigrodzki To: Gerontology Research Group Sent: Monday, June 16, 2014 12:07 PMSubject: Re: [GRG] How much do mouse L/S experiments cost? (Was: blocking a pain receptor extends mouse … )
On Sun, Jun 15, 2014 at 7:22 PM, Brody Holohan wrote:
I disagree that universities are wasteful for this sort of thing. Yes, they add indirect costs, but by and large you get what you pay for there, unless you’re doing something very well characterized like the phamacokinetics/dose escalation/pre-clinical mouse
work that CROs are mainly used for.
Well, they are also quite useful for chemical synthesis work off a protocol, developing bacterial strains, developing fermentation protocols. You should not expect world-class cutting-edge inventiveness but you will get competent (hopefully) application of routine techniques.
Visiting the CRO in person is a good idea, especially before a larger campaign – sometimes you find weirdness.
For example, for one of my recent experiments, I had access to a world-class barrier facility, around the clock veterinary services, core facilities for mass spec, DNA sequencing, expression arrays, imaging, PK, and collaborators with experience in mouse
survival surgery and the imaging model system I was using. I also was one mailing list away from borrowing small quantities of virtually any reagent I needed or getting training or advice in almost any veterinary/molecular/cell biology technique. Getting
that outside a university setting would have involved purchasing a number of very expensive machines and hiring highly qualified contractors, or, more likely, just not getting the support I needed there and ending up with bad/unclear data. Universities are
a good site for studies where you don’t exactly know what you’re going to need to start out with, or when you’re innovating in terms of protocol (as all aging studies will have to). It is also worth noting that while universities throw on indirect costs,
they also pay their staff considerably worse than the private sector does for equivalent education, so the price tag may not be as different as you’d think, though I don’t know enough about the price ranges for CROs to say for sure.
There are benefits to cooperation with an academic group and we had some very good experiences with contract-based fermentation development at a US university. But for pharmacological dosing studies a CRO is hard to beat in terms of prices. For small short term studies you can go as low as 10k per study.