Re: [GRG] Dr. Coles’s cancer showing signs of remission

Greetings,

Dr. Coles called me this afternoon and asked me to inform the Gerontology Research Group that, after the latest round of chemotherapy, the tumors in his liver and pancreas have shown signs of remission/shrinkage. They are not gone but this is the first report where they were smaller than the previous test.

Dr. Coles is planning to take a trip to New York June 22-28, 2014 and will be mostly unavailable.

Dr. Coles will begin his next round of chemotherapy on July 1, 2014.

This battle is not over…Dr. Coles is fighting to come back and defeat the cancer. Thanks to everyone who has helped by donating to Dr. Cole’s cancer treatment fund and may you continue to do so if able.

Sincerely,

Robert Young

Senior Database Administrator

Gerontology Research
Group

From: Rafal Smigrodzki To: Gerontology Research Group Sent: Monday, June 16, 2014 12:07 PMSubject: Re: [GRG] How much do mouse L/S experiments cost? (Was: blocking a pain receptor extends mouse … )

On Sun, Jun 15, 2014 at 7:22 PM, Brody Holohan wrote:

  I disagree that universities are wasteful for this sort of thing. Yes, they add indirect costs, but by and large you get what you pay for there, unless you’re doing something very well characterized like the phamacokinetics/dose escalation/pre-clinical mouse
work that CROs are mainly used for.

Well, they are also quite useful for chemical synthesis work off a protocol, developing bacterial strains, developing fermentation protocols. You should not expect world-class cutting-edge inventiveness but you will get competent (hopefully) application of routine techniques.

Visiting the CRO in person is a good idea, especially before a larger campaign – sometimes you find weirdness.

 

  For example, for one of my recent experiments, I had access to a world-class barrier facility, around the clock veterinary services, core facilities for mass spec, DNA sequencing, expression arrays, imaging, PK, and collaborators with experience in mouse
survival surgery and the imaging model system I was using.  I also was one mailing list away from borrowing small quantities of virtually any reagent I needed or getting training or advice in almost any veterinary/molecular/cell biology technique. Getting
that outside a university setting would have involved purchasing a number of very expensive machines and hiring highly qualified contractors, or, more likely, just not getting the support I needed there and ending up with bad/unclear data. Universities are
a good site for studies where you don’t exactly know what you’re going to need to start out with, or when you’re innovating in terms of protocol (as all aging studies will have to).  It is also worth noting that while universities throw on indirect costs,
they also pay their staff considerably worse than the private sector does for equivalent education, so the price tag may not be as different as you’d think, though I don’t know enough about the price ranges for CROs to say for sure.

There are benefits to cooperation with an academic group and we had some very good experiences with contract-based fermentation development at a US university. But for pharmacological dosing studies a CRO is hard to beat in terms of prices. For small short term studies you can go as low as 10k per study.

Rafal

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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