Ignoring the currently impenetrable origin of anything and everything, and the vexation of consciousness, the basis of life appears to be nothing more than a novel fulfillment of the second law of thermodynamics. Life fills a niche in the breakdown of complex molecules into simple ones, and that appears to be the whole story. If so, then the statement “She [Nature] does not share our prolongevity agenda” is incorrect. Sticking with the anthropomorphizing for a moment, Nature surely wishes we would live longer, so as to speed the leveling of energy levels in the universe, but She has found that perennial renewal works better, given a very large but not infinitely capable biochemical toolbox (DNA/RNA) to work with, and an environment that keeps changing.
…But of course nature really doesn’t care because – as far as we can tell – there is no consciousness to this overarching body of rules we call nature. Nature is indifferent. Nature doesn’t care about me, but it also doesn’t not care about me. A stout thread of hope can thus be found in the fact that there is nothing in nature that opposes our efforts to achieve indefinite healthspan.