Re: [GRG] How much do mouse L/S experiments cost? (Was: blocking a pain receptor extends mouse … )

Hi Kingsley,
I don’t have a handle on how much mouse life span experiments cost.
I found it interesting that ablation of certain pain receptors
improved health and lifespan. It coincides with improvement in same
with the loss of the sense of smell.
Regene

On Sat, 14 Jun 2014 19:58:59 -0700 kingsley@loaner.com wrote:
>For what it’s worth, I was reviewing this
>experiment for addition to my big spread sheet,
>and I was surprised at how expensive it evidently
>was.
>
>It reportedly cost over $1 million to house and
>care for the mice over several years[1].
>
>Do you happen to know how much mouse life span
>experiments typically cost?
>
>Thanks,
>Kingsley
>
>Reference
>
>[1] No Pain, Time Gained,
>http://ift.tt/1hVKfWM
>On 05/24/14 14:04, regene1@hushmail.com wrote:
>> http://ift.tt/TygrVL
>>
>> (Anti-aging: blocking a pain receptor improves metabolic health
>and
>> lifespan in mice)
>>
>> TRPV1 Pain Receptors Regulate Longevity and Metabolism by
>> Neuropeptide Signaling
>>
>> Céline E. Riera
>> , Mark O. Huising
>> , Patricia Follett
>> , Mathias Leblanc
>> , Jonathan Halloran
>> , Roger Van Andel
>> , Carlos Daniel de Magalhaes Filho
>> , Carsten Merkwirth
>> , Andrew Dillin
>>
>>
>> Highlights
>>
>>
>> •Mutation of TRPV1 extends lifespan in mice and worms via
>> CRTC1/CREB signaling
>> •TRPV1 mutant mice have normal growth but have a youthful
>> metabolism late in life
>> •TRPV1 impact on metabolism through secretion of CGRP, an
>insulin
>> secretion blocker
>> •Chemical inhibition of CGRP increases metabolic health at old
>age
>>
>>
>>
>>
>> Summary
>>
>> The sensation of pain is associated with increased mortality,
>but
>> it is unknown whether pain perception can directly affect aging.
>We
>> find that mice lacking TRPV1 pain receptors are long-lived,
>> displaying a youthful metabolic profile at old age. Loss of
>TRPV1
>> inactivates a calcium-signaling cascade that ends in the nuclear
>
>> exclusion of the CREB-regulated transcriptional coactivator
>CRTC1
>> within pain sensory neurons originating from the spinal cord. In
>
>> long-lived TRPV1 knockout mice, CRTC1 nuclear exclusion
>decreases
>> production of the neuropeptide CGRP from sensory endings
>> innervating the pancreatic islets, subsequently promoting
>insulin
>> secretion and metabolic health. In contrast, CGRP homeostasis is
>
>> disrupted with age in wild-type mice, resulting in metabolic
>> decline. We show that pharmacologic inactivation of CGRP
>receptors
>> in old wild-type animals can restore metabolic health. These
>data
>> suggest that ablation of select pain sensory receptors or the
>> inhibition of CGRP are associated with increased metabolic
>health
>> and control longevity.
>>
>>

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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