Re: [GRG] New Member Announcement and RE: Does Ibuprofen slow the aging process?

On Fri, Dec 19, 2014 at 3:57 PM, John M. “Johnny” Adams, GRG Exec Director wrote:

    Deactivating the permease, which rapidly takes in amino acids like tryptophan, has an unexpected effect on cell aging. “Ibuprofen slows the transport of     amino acids, and the protein synthesis slows down,”   Kennedy tells Yahoo Health. Slower protein synthesis equals slower aging — which equates to                 increased longevity across all the species. After yeast, the same bump was shown in fruit flies and worms. 

    This study is the first to identify a potential new drug candidate to target aging: ibuprofen. According to Kennedy, if the drug had the same effect in humans,     something that needs to be tested, it could mean a significant enhancement of healthy aging. 

 

This fits in with the “slowing the rate of aging” hypothesis by slowing the metabolic activity of cells. It must be important to note, however, that too much of an effect (total disruption of protein synthesis) would be a huge negative. So, this is an issue of getting more years out of life by slowing, not stopping, metabolic activity in cells.

 

### Slowing metabolic activity is a usually a sign of impending death in humans, especially in the brain. There is to the best of my knowledge no convincing evidence that aging is a by-product of high metabolic activity, in fact, there are good reasons to think otherwise (longevity of highly metabolically active animals, for example). Metabolic suppression is also a hallmark of many pathological states, such as diabetes, metabolic syndrome, and metabolic activation or increased metabolic capacity is found in organisms on CR or in exercising humans, so the preponderance of evidence favors high metabolic activity as associated with slowing of aging, at least in mammals.

I would hypothesize that the protein synthesis modulation effect seen with ibuprofen may trigger enhanced mitophagy, which is most likely the true mediator of anti-aging effects.

Rafał 

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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