On Fri, Dec 19, 2014 at 3:57 PM, John M. “Johnny” Adams, GRG Exec Director wrote:
Deactivating the permease, which rapidly takes in amino acids like tryptophan, has an unexpected effect on cell aging. “Ibuprofen slows the transport of amino acids, and the protein synthesis slows down,” Kennedy tells Yahoo Health. Slower protein synthesis equals slower aging — which equates to increased longevity across all the species. After yeast, the same bump was shown in fruit flies and worms.
This study is the first to identify a potential new drug candidate to target aging: ibuprofen. According to Kennedy, if the drug had the same effect in humans, something that needs to be tested, it could mean a significant enhancement of healthy aging.
This fits in with the “slowing the rate of aging” hypothesis by slowing the metabolic activity of cells. It must be important to note, however, that too much of an effect (total disruption of protein synthesis) would be a huge negative. So, this is an issue of getting more years out of life by slowing, not stopping, metabolic activity in cells.
### Slowing metabolic activity is a usually a sign of impending death in humans, especially in the brain. There is to the best of my knowledge no convincing evidence that aging is a by-product of high metabolic activity, in fact, there are good reasons to think otherwise (longevity of highly metabolically active animals, for example). Metabolic suppression is also a hallmark of many pathological states, such as diabetes, metabolic syndrome, and metabolic activation or increased metabolic capacity is found in organisms on CR or in exercising humans, so the preponderance of evidence favors high metabolic activity as associated with slowing of aging, at least in mammals.
I would hypothesize that the protein synthesis modulation effect seen with ibuprofen may trigger enhanced mitophagy, which is most likely the true mediator of anti-aging effects.