Hi Bryant, Has there been an update on this study and/or on your stem cell 100 plus supplement formulation?
On Thu, Aug 8, 2013 at 12:21 AM, Bryant Villeponteau wrote:
That the Life Extension Mix does not extend mouse life is not surprising to us at Genescient. We have spent years testing many substances for longevity effects in Drosophila. And to Gwern Branwen point, we use 1500 flies per group to get high statistical probability. Even when we have seen positive effects of individual substances on longevity, the combination of 3 to 8 substances typically decreased lifespan or was less effective than the best single substance. Why is that so? We think that it is the network of gene expression that is important in aging and predicting exactly how a group of substances is going to affect the gene network is impossible given our current understanding of gene interactions.
So our strategy has been to identify the best longevity gene targets and then screen for a SYNERGISTIC group of substances that acts on those genes. It is not easy to do and it takes an endless number of screening assays, but it appears to be the only way to check whether a combo set of substances will act to elongate life better than single components. Of course, the critics will say it is only flies, but the longevity genes appear to be highly conserved in flies, mouse, and humans. In any case, we are now about to test our best set of 8 synergistic components in a small human clinical trial on a major age-related condition (coordination and memory loss in subjects with moderate cognitive impairment) that has defied attempts to treat it using standard one-pathway pharmaceutical treatments. If the multi-pathway theory of aging is correct, it may just work!