Re: [GRG] Plan A Footnote

Paul: I am in full
agreement with your critique breaking down Plan A into Plans [A1 and
A2],
which has a strong intersection with Aubrey de Grey’s SENS plans and with
Ray Kurzweil’s
Bridge Plans {1, 2, and 3}.  We clearly need to have senescent cells
undergo Programmed Cell
Death (PCD) [i.e., apoptosis] to make room for fresh stem cells in the
proposed complex of heterochronic
cells in our new tissue environment [recall the work with mice at the
Mayo Clinic published in Nature in 2011
in which the death of non-functional senescent cells —  those that
only suck up resources and don’t pull
their own weight — is significantly beneficial for longevity.  How
to trigger apoptotic destruction of such
dysfunctional cells by detecting membrane-level senescent surface-markers
that were not placed there
a priori by investigators {before birth} is not yet understood {but I
have it on good authority that Mayo
researchers are working on this as a top priority} could be eliminated in
this way along with mitochondrial
atrophy/fatigue as a major complication of aging.] Likewise, we eliminate
the problem of intracellular
lipofuscin particles {yellow/brown black fatty undigestible trashy sticky
junk that has been known
for decades by pathologists to accumulate systematically in the cytoplasm
of old cells as a reliable biomarker
of chronological age to the point that it was described in an early
chapter of  “Little Robins” textbook of
Pathology back in the 1970’s.} Of course, there is also the problem of
Extracellular-Matrix (ECM) Trash, 
but this needs to be obviated by new instructions to {angry/sensitized}
macrophages to gobble it up,
providing it could be properly tagged for recognition by specific
monoclonal antibodies [think of autophagy
of intracellular, tired or misfolded proteins in the cytoplasm that are
subsequently digested by lypozomes,
which Nature created as a distinguished organelle for this purpose, just
as She created two generations
of sharp teeth {baby and adult}so that we could better chew our food.
“Little Red Ridding Hood: Grandma,
what sharp teeth you have? Big Bad Wolf [in drag]: All the better to eat
you with, my dear!” 🙂
Wolf-style carnivores, not herbivores, tend to hunt in packs; but we will
forgive this omission in our
fairy-tale literature, since this cautionary tale ends well with
the arrival of the woodsman and his trusty
axe (technology wins the day)]. Plan B needs a lot of work
too, as Dr. Greg Fahy pointed out. — Steve
Coles

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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