Re: [GRG] Rebuttal — was RE: NewAbs: TC-2153 for AD (in Mouse Model) STEP In…


Well said, Johnny.  Cheers to you.





In a message dated 8/8/2014 9:51:00 A.M. Pacific Daylight Time, writes:

Dear GRG

As a GRG discussion list
member – as well as co-admin and list co-creator (assisting Dr. Coles in the
original “Majordomo” list installation back in 2003) I will chime in on the
post below.

1. Re. Steve’s “Would
Nature ever think to make such a small molecule that looked like this? 🙂

Note the emoticon “:-)” at
the end.  Clearly the intent of the phrase is light-hearted, and taking
an intentional liberty.

Of course natural selection
is mechanical, and dispassionate.  We know that.

In an informal professional
discussion such as our GRG list, I personally feel use of such phrase IS
appropriate — and sometimes even brings color and life to the
discussion.  This can be like a fresh breeze compared to the dry
scientific writing we spend much of our lives in.

2. Re. the criticism of Dr.
Coles’ statement, the anthropomorphic statement below “ . . . this molecule
has actually been designed and made by nature.”. 

I do not believe nature
designs.  This implies intent, and is actually similar to “Would Nature
ever think . . .”.


3. On the GRG discussion
list, correction or criticism should be presented in a courteous tone. 

This is not just my
personal opinion.  In December of 2012 we did a survey of GRG email
discussion list members, asking for guidelines.  This was high on the
list of requests by members.

Many criticisms should be
taken up with the person directly, not on a public forum sent to all 533

We all make mistakes, so if
a member learns they have actually made a statement in error, they will likely
acknowledge it.

And if a member should in a
moment of haste write something that is rude or mean-spirited, they should

4. I personally feel it
inappropriate to scold even a novice in such a manner, let alone a world class
emeritus member of our community who has been a researcher, teacher, mentor
and friend, and selflessly gives so much of his time making great
contributions to our shared mission.


M. “Johnny” Adams


From: [] On Behalf Of
Paul WakferSent: Thursday, August 07, 2014 6:56
PMTo: grg@lists.ucla.eduSubject: Re: [GRG] NewAbs:
TC-2153 for AD (in Mouse Model) STEP

On 14-08-07 04:19 PM, L. Stephen Coles M.D. Ph.D.

Would Nature ever think to make such a
small molecule that looked like this? 🙂 — Steve Coles

Steve, Nature doesn’t
think!! Please refrain from such anthropomorphic language which makes
you look extremely unprofessional and even unscientific (if not actually
brainless – but I know you’re not).Finally, since humans are part of
nature, this molecule has actually been designed and made by nature. The whole
idea of humans being apart from nature is a highly mischievous fundamentally
invalid notion.Please stop promoting these damaging ideas and


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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