Re: [GRG] Rebuttal — was RE: NewAbs: TC-2153 for AD (in Mouse Model) STEP Inhibitor

Damien: I am with both you and Paul at one level, but then I
have to take out my anger on the designers
of the English language for not providing us with simple English words to
express in a compact manner
how Nature designs molecules to perform certain functions but not others
in  what seems to be a capricious
manner.  And when we, as  chemical engineers, design molecules
that do better at certain functions than
Nature does, why can’t it be appropriate to complain about why She didn’t
do what we can do, employing
the poetic figure-of-speech known as “personification” (or
“reification”) in the same fashion as gamblers may
complain at the roulette wheel when they lose, “Lady Luck was not
kind to me today!”  If I have to recapitulate
the random/stochastic basis for Darwinian evolution at every turn, when I
seek to complain about Nature’s
“foolish/ludicrous” choices, I would constantly lose the time
it takes to do so.  So, in the mean time, I will continue
to use a smiley face 🙂 to indicate “just kidding,” when I
anticipate that there will be push back by the linguistically
rigorous, science types among us.  BTW, if I recall correctly, I
already did that in my original post, anticipating such
push back.  Furthermore, I don’t believe that it’s unscientific to
call a spade a spade and continue to remind us
poetically that Nature did not provide us with a Garden of Eden at the
beginning of recorded history. She is a
superbly nasty and cruel creature, with Her own agenda, and for the
moment, we are Her prisoner. 😦
If we only stuck to discussing pure medical science, we might lose touch
with our original motivation to push
science forward.  When we see five years of industrial-strength
research, such as noted at Yale, we need
to acknowledge it as really cutting edge and a major stab in the back of
our life-long enemy.    — Steve

At 01:56 PM 8/8/2014, you wrote:
    I’m with Paul
Wakfer in every particular of his original post and rebuttal to Johnny’s
In regard to anthropomorphism and, even more stringently, playful
invocation of designer gods,
people on a scientific list such as this just have to STOP DOING THAT.
It’s bad for  our health.
— Damien Broderick


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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