Re: [GRG] Senescence wrongly associated with aging: Manuel Serrano CNIO

Hello,

my current view of human basic aging (& mammalian?; view hold for two years; I
guess by many here too) is that we get old mostly(1) because we regenerate much less fast and two main aspects (that, as we get old, become considerable and grow exponentially) are probably behind and probably interlinked:

1– accumulation of senescent cells // inadequate removal of them as they
certainly come for a reason such as preventing further local damage

2– disparition of active stem cells

Possibly (1) could lead to (2) : either because the body needs to “make some room” to maintain regeneration, or because the cell-division-and-inflammatory signals of the senescent cells block the regenerative process.

I guess that many here had (/have) the same view and I understand that Manuel Serrano’s views greatly enlights us on some aspects but without contradicting the above. Does anyone view the above as very inadequate and if so for what reason(s)?

(Thank you in advance for deciphering this together!)

Cheers

Edouard

(1) of course a zillion things happen as we grow but some are more dramatic than others

(2) among other, the mayo clinic mice with special senescent cell accumulation and removal highlights it well

(3) among other, the recent case of Hendrikje van Andel-Schipper (115 women who was found to have only 2 –!– active hematopoetic stem cells) highlights it well

De : “regene1@hushmail.com” À : grg@lists.ucla.edu; paul@science-of-aging.com Envoyé le : Mardi 15 juillet 2014 1h07Objet : Re: [GRG] Senescence wrongly associated with aging: Manuel Serrano CNIO

Thanks, Paul.Yes I thought the article was quite interesting and would have implications for aging and age related diseases.RegeneOn Mon, 14 Jul 2014 15:38:13 -0700 paul@science-of-aging.com wrote:>The link got broken in the email, so here is an updated version:>http://goo.gl/fUhUkQ>>Thanks for sending this on Regene. I remember now that the Google >URL>shortener: goo.gl gives you statistics on how many times your link >gets>clicked. This can be
a way for you to get feedback on how many >people are>clicking on the articles.>>The paper itself is quite interesting and look forward to seeing >what they>find out about moles.>>>On Mon, Jul 14, 2014 at 2:56 PM, wrote:>>> MANUEL SERRANO PROPOSES A NEW VISION OF A PROCESS WRONGLY>> ASSOCIATED WITH AGING: SENESCENCE>>>> PDF file at:>>>> http://ift.tt/1jsvBan>> 11jul14-en.pdf>>>>

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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