my current view of human basic aging (& mammalian?; view hold for two years; I
guess by many here too) is that we get old mostly(1) because we regenerate much less fast and two main aspects (that, as we get old, become considerable and grow exponentially) are probably behind and probably interlinked:
1– accumulation of senescent cells // inadequate removal of them as they
certainly come for a reason such as preventing further local damage
2– disparition of active stem cells
Possibly (1) could lead to (2) : either because the body needs to “make some room” to maintain regeneration, or because the cell-division-and-inflammatory signals of the senescent cells block the regenerative process.
I guess that many here had (/have) the same view and I understand that Manuel Serrano’s views greatly enlights us on some aspects but without contradicting the above. Does anyone view the above as very inadequate and if so for what reason(s)?
(Thank you in advance for deciphering this together!)
(1) of course a zillion things happen as we grow but some are more dramatic than others
(2) among other, the mayo clinic mice with special senescent cell accumulation and removal highlights it well
(3) among other, the recent case of Hendrikje van Andel-Schipper (115 women who was found to have only 2 –!– active hematopoetic stem cells) highlights it well
De : “email@example.com” Ã : firstname.lastname@example.org; email@example.com EnvoyÃ© le : Mardi 15 juillet 2014 1h07Objet : Re: [GRG] Senescence wrongly associated with aging: Manuel Serrano CNIO
Thanks, Paul.Yes I thought the article was quite interesting and would have implications for aging and age related diseases.RegeneOn Mon, 14 Jul 2014 15:38:13 -0700 firstname.lastname@example.org wrote:>The link got broken in the email, so here is an updated version:>http://goo.gl/fUhUkQ>>Thanks for sending this on Regene. I remember now that the Google >URL>shortener: goo.gl gives you statistics on how many times your link >gets>clicked. This can be
a way for you to get feedback on how many >people are>clicking on the articles.>>The paper itself is quite interesting and look forward to seeing >what they>find out about moles.>>>On Mon, Jul 14, 2014 at 2:56 PM, wrote:>>> MANUEL SERRANO PROPOSES A NEW VISION OF A PROCESS WRONGLY>> ASSOCIATED WITH AGING: SENESCENCE>>>> PDF file at:>>>> http://ift.tt/1jsvBan>> 11jul14-en.pdf>>>>