Re: [GRG] What successes have there been in the creation of aging therapies?

And, for proof on the Venture Capital side, Organovo is pretty good. From start-up to NYSE in 5 years. Market cap has been as high as $1 billion (so far). New parts for people. Real human 3d liver tissues for toxicology studies are available RIGHT NOW. Kidney assays coming soon.

In general:

We need to get the crapoutofus (lysosens, autophagy etc)

We need to have replacement parts (molecular and macro)

We need to know what’s going on inside ourselves for each and every one of our “undiscovered countries” in real time/all the time.

We need to figure out what we’ll do with ourselves when we’ve automated ourselves out of economic usefulness

On Thu, Jun 5, 2014 at 10:11 AM, David Gobel wrote:

Hi Johnny, As the original poster/questioner, you asked what successes have there been for aging therapies. Two things – you said Rapamycin didn’t work, but the 3 center ITP studies in mice showed that it definitely did work as far as I know. What did I miss?

Second, I would suggest that it would be worthwhile to change the question from “aging therapies” to “successes that have lead to life extension” as there are no doubt many. Defeat of polio, smallpox, death by childbirth (mother and/or baby), heart and other surgeries (on a historical scale, these are NEW methods), antibiotics etc. In other words, reframe the question to support the following follow on discussion:

All of these successes were battles won. Unfortunately we seem to continue to ignore our actual enemy, the universal decline we call aging – and while we have won battles which PROVES we can win with focus and funding, we have avoided fighting the actual war head-on.  We CAN do this – So we must.

On Sat, May 31, 2014 at 4:02 PM, John M. “Johnny” Adams wrote:

Dear GRG Member,

 

One of my expert fundraising consultants asked “What successes have there been in the creation of aging therapies?”

 

Donors will ask this question.  We need compelling answers.   (However – if were already 100% successful we’d be young again and off doing something else!)

 

So I ask you: What successes have there been in the creation of aging therapies?

Your input would be appreciated – and help build a case statement to get the money we need!

 

A model and initial list are below.  Please add to it, and CORRECT any mistakes.

*** FIRST DRAFT – IN PROCESS  March 30 2014 ***

 

One model: the March of Dimes.  Not aging R&D, but an example of success when we put our minds and resources to it.

The National Foundation for Infantile Paralysis, better known as the March of Dimes, established a polio patient aid program and funded research for vaccines developed by Jonas Salk, MD and Albert Sabin, MD.

These vaccines effectively ended epidemic polio in the United States.

 

Three categories of Successes in Aging:

1)     Conventional methods available now

–        Nutrition, exercise, adequate water, moderate and appropriate nutritional supplements

–        Medical diagnosis and treatments

–        Appropriate pharmaceutical interventions

o   Possibly off label drugs prescribed and monitored by high level expert — example metformin, statins

–        Reducing risks – examples: crash resistant autos, household safety (care not to slip from ladder, etc), personal protection against crime

 

2)     Repair Solutions (some available now, others under development)

–        Stem cells

o   One recent example of an advance: Mice Walk After MS Like Spinal Condition  5/14/14 http://ift.tt/1o61J2g

–        Kidney transplants

–        Childrens’ leukemia – used to be nearly always fatal, now nearly always successful treatment

–        Artificial organs

–        Tissue engineering

–        SENS – Strategies for Engineering Negligible Senescence (www.sens.org) kind of like million mile Volvo

–        Medical, biotech

–        New: Ultra sensitive chip for early cancer detection (5/19/2014)

–        FoldRx?  Is this the company that was acquired by Pfizer that was created from knowledge obtained from the work of the Supercentenarian Research Foundation and GRG members and others listed here:

http://ift.tt/1m1N3xs

and http://ift.tt/1oIacLN

 

3)     Aging Interventions

–        What didn’t work – resveratrol, rapamycin, sirtuins

–        Probably works in humans: Caloric restriction

–        Probably works in humans: Methionine restriction

o   Exciting work with metformin, gut microflora and methionine restriction

–        One example: Interactions of multiple factors (5/16/14 http://ift.tt/Tcp1t3 )

 

Your input would be appreciated – and help build a case statement to get the money we need!

 

Johnny

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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