Re: [GRG] Cnio telomere therapy

Good question and something we have been working on. We have been searching host countries for “right to try” use scenarios. I have traveled to a number of potential host countries. Some frown upon experimental therapies that involve the patient paying for the therapy but offer no financial assistance otherwise. Some have no infrastructure for gene therapy but are marginally set up for stem cell therapies. Some have socialized medicine and cannot afford to bring a new therapy to their people at large even if it proves viable.  It would be great if we could get allocation on USA soil but a lot of “right to try” seems targeted at small molecule approaches and not gene therapy, indicative of a new market with few results outside phase three trials. That being said, we have a lot to learn and could use guidance.

One of the biggest problems is that the therapies we are working on are very expensive to build at GMP, so cost to the patient right now might be out of most persons grasp. BioViva is seeking investment to bring those costs down significantly. By building therapies with a small team without 5 paper pushers behind each scientist we can achieve marked results, then to work on a couple news ways of increased therapy production.

We can use gene therapies with safety/efficacy and re-use/re-allocate them to test for longevity based purposes. We can also expedite large animal studies on therapies that show promise for cognitive enhancement, age reversal and other benefits that need further testing to become life saving biotechnologies.  There are over 164 gene therapies in trials around the world, we sit and gather their data. We look at the data in a very different way than the 1 therapy for 1 disease model. In the mean time we have enough data to start, but funding is the big issue.

I believe we will build the fastest pipeline to results, ethics and medicine have been badly interwoven. To me it is unethical to let people die without trying a treatment that could save their life and improve the lives of millions.

Best,Elizabeth Parrish

Liz,L.Parrish – Skype

On Dec 30, 2014, at 11:49 PM, steve hill wrote:

Could the number of states initiating “right to try” programs for the Terminally ill be an avenue towards faster Human trials?

There are a number of promising methods out there but nothing will happen unless testing in-vivo is tried. The recent use of young blood introduced to an aging system has shown reversal of some aging so perhaps this could be combined with Telomere restoration as a combined therapy?

From: Liz Parrish To: Gerontology Research Group Sent: Wednesday, 31 December 2014, 5:00Subject: Re: [GRG] Cnio telomere therapy

Sierra Science has done a lot of work in this field and I appreciate and support Bill Andrews’ expertise in this area. He is the authority on the matter of telomerase. Werner syndrome and Progeria  are both accelerated aging diseases and are marked by short telomeres.

BioViva will not take telomere lengthening therapies off our top-ten anti-aging list until therapies have been tried in-vivo at the level needed to lengthen the telomeres to full length and the data collected. Animals studies point to no and even reduced risk of cancer. I believe this follow through method needs to be instated with all potential therapies before they are moved aside. We can not move forward on hypothetical reasoning. Human data is greatly needed. Best,Elizabeth Parrish

Liz,L.Parrish – Skype

On Dec 30, 2014, at 12:51 PM, wrote:The earlier Mouse study paper is here: increasing telomere length is not the only aspect of aging but it’s certainly a key factor and short telomeres lead to a host of problems. I understand from the vector they used applying this to humans would not be difficult.Another consideration is that mice are not the best model as they are not as focused on telomere attrition as we are and have longer telomeres. It could be possible that any benefits may be considerably increased in a Human.There has been considerable debate that it causes cancer though from my research recently it appears that telomeres of optimal length protect against it, whereas short telomeres encourage it. I’m not an expert of course but it does seem telomere rejuvenation is a worthwhile avenue.


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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