Here are three papers where Maria Blasco’s group has done work with telomerase usually combined with one or another type of cancer protection to extend longevity in mice.
Tomas-Loba A, et al. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell. 2008;135:609–622.Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA (2013)
Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to
Increase Health Span and Extend Mouse Longevity. PLoS ONE 8(1):
doi:10.1371/journal.pone.0053760Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F,
Blasco MA. Telomerase gene therapy in adult and old mice delays aging and
increases longevity without increasing cancer. EMBO Mol Med. 2012
Aug;4(8):691-704. doi: 10.1002/emmm.201200245.
On Mon, Jan 5, 2015 at 3:13 PM, Edouard Debonneuil wrote:
The main result of the article would suggest that cancers are mostly due to errors in the DNA replication during the division of stem cells. A mini thought on a life extending strategy then:
Mechanically, it seems that the first way to make us live longer would be to restoring a fast body renewal as we grow older. Perhaps we’ve missed such life extensions because they were counterbalanced by more cancers? What would be the typical therapies/hormones that accelerate body renewal??? Perhaps they could be tested in cancer-resistant mouse models.
Would be happy to have views from anyone on this.
De : CAC Gmail À : Gerontology Research Group Envoyé le : Lundi 5 janvier 2015 18h14Objet : Re: [GRG] cancer risk
Also an interesting commentary on how this article has been covered by journalists. Especially the claim that many or most cancers come down to “bad luck”.