To Coote re: “.. if cancer was caused by errors during stem cell division, then surely it should be more prevalent in the rapid growth phase following puberty?” I like your thinking. So for example to the extent that different organ systems grow rapidly at different stages of life could data from something like The Great Chinese Famine (roughly 1958-1961) be looked at for different age cohorts and cancer rates for various organ systems compared? (Skeletal structures in males post-puberty and bone cancer? Rapid brain growth through age five and brain cancers? Etc.)
On Tue, Jan 6, 2015 at 1:03 AM, Thomas Coote wrote:
Greetings Edouard and all Members,
Perhas this is a naive thought but, if cancer was caused by errors during stem cell division, then surely it should be more prevalent in the rapid growth phase following puberty? But, as we know, about 90% of cancers are diagnosed in people over the age of 50, when stem cell activity is in decline and stem cells are more quiescent.
Hormones that accelerate body renewal for example are HGH and testosterone, both with rather chequered results as far as life extension goes.
Just some musings.
New Year Greetings to all.
On Tue, Jan 6, 2015 at 12:13 AM, Edouard Debonneuil wrote:
The main result of the article would suggest that cancers are mostly due to errors in the DNA replication during the division of stem cells. A mini thought on a life extending strategy then:
Mechanically, it seems that the first way to make us live longer would be to restoring a fast body renewal as we grow older. Perhaps we’ve missed such life extensions because they were counterbalanced by more cancers? What would be the typical therapies/hormones that accelerate body renewal??? Perhaps they could be tested in cancer-resistant mouse models.
Would be happy to have views from anyone on this.
De : CAC Gmail À : Gerontology Research Group Envoyé le : Lundi 5 janvier 2015 18h14Objet : Re: [GRG] cancer risk
Also an interesting commentary on how this article has been covered by journalists. Especially the claim that many or most cancers come down to “bad luck”.