Re: [GRG] Major Mouse Testing Program — slides to be sent for the New Year!

As Craig pointed out, CR controls are just as important as regular
controls and all treatment groups should be monitored for crypto-CR
since very often with anything at all foreign to a normal mouse food
intake, there will be an automatic reduction of intake, which in
itself will have a life/health extending effect if not too great.
I would also suggest that all the mice be in similar enriched
environments rather than the totally unrealistic small cages with
nothing of interest to do.
In addition, the experiments should not be done with certain
isolated ingredients that may increase requirements for other
ingredients. Rather each diet needs to be a fully consistent whole
to the extent that is known or even suspected. There are many such
interactions, some of which are well known but many of which are
not. Therefore, it would be a good idea to post to this list and
elsewhere the precise entire set of parameters planned for each
mouse group *before* any further action is taken, so that all such
potentially negative problems can be eliminated (at least all that
are currently known by members of the groups to which you post).
On 15-01-06 11:19 AM, Craig Cooney

Dear Edouard,

Thank you for sharing your ppt with us.  Because I didn’t see
many specifics on how the studies will be run my
recommendations include using purified diets like AIN-93 (not
NIH-31) and to measure diet intake to determine treatment
dosage and to monitor for inadverent CR effects.  Also HET
mice (Dave Harrison’s recommendation) would be best but
another good option (less expensive) would be a well
established cross (albeit if only an F1) such as B6C3F1 mice
as Steve Spindler used in some of his studies.  Inclusion of
positive controls of CR mice in the diet studies and known
life extending genes in the TG studies (like the Maria Blasco
papers I sent today) is important. 


On Tue, Dec 30, 2014 at 10:52 AM,
Edouard Debonneuil wrote:

Dear GRG members,

Last year and two years ago, Dr
Coles and Johnny had kindly put me in contact
with various mouse lifespan specialists — many
being here — as I was wondering how to
accelerate the ongoing robust mouse lifespan
tests done by the ITP and specific labs, by
doing large series in parallel in order to have
a robust set of geroprotective therapies that
will transform the field and our lifespans in a
few years (that’s the hope :). I have rapidly
learned that others had wanted to do similar
things already but geting the money is the tough

With the help of various friends,
especially from Longévité Santé & ILA &
the Longevity Party (but not only, in particular
Heales – eg the project was presented at EHA2014 –
and of course GRG as indicated) we have put
together some experts in such rodent lifespan
tests, health tests and regenerative medicine,
with top quality rodent facilities, who are
ready for the adventure to set up the big lines
first and look for funds then. It is
perhaps not the first time that such a thing
is attempted, but given the advances in life
extension awareness today, the power of social
networks, the possibilities of gene therapy
today, and the databases of putative
geroprotective therapies, we think it is the
right time to do it, with the help of those

=> This is how we got to the slides
attached ; online we will put pdfs
for the New Year, but given the level of GRG
people here may want to suggest improvements
based on the slides, perhaps even today so that
we can consider them for the New Year. If you are interested
to help, please have a look at page 13. The
slides are currently being translated in
French, German, Swedish, Dutch, Russian,
Romanian. For those who wish to donate, if you
live in the USA please wait for a few
days/weeks to donate to a 501c3 organisation
for tax discounts.

that 2015 will allow to start the project,




About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
This entry was posted in Uncategorized. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s