Re: [GRG] Dr Dhahbi’s Parabiosis article

Thank you, in that old paper that I had read in details things are actually not so clear:

— there is a huge death following surgery, which in fact leads to a lack of precision when trying to mathematically rectify for such death in lifespan estimations

— the following is sufficient to explain(*) the results: parabiosis with a dead or almost dead animal has a negative influence on the other partner

So the design in itself had that limit to not being able to demonstrate a life extension unless it is a very strong life extension. With injections, that are minimally harmful and are one-way transfers, we could have demonstrated a life extension if there was a small-or-medium one, but that’s not what the results showed at least in our conditions. So, if I am not mistaken, it looks like twice a neutral result. But based on the numerous short term positive effects that were published, we can still hope in humans at least for Alzheimer’s.

By the way I have various indications in mice and rats (yes… would need to take the time to list articles) that IGF-1 inhibition/rapamycin/everolimus enhances neurogeneration in conditions of neurodegenerescence: I wouldn’t be surprised if everolimus could act against Alzheimer’s. Since Novartis is testing it to boost the response to flu vaccines, it looks like testing on Alzheimer’s could be quite feasible (?).

Cheers

Edouard

(*)

a) heterochronic young partners did not live long…possibly simply because their aged partner were dying. Indeed I had done some copy and paste of portions of the lifespan curves under paintbrush and it is (sadly) sufficient to explain the young survival curves

b) vice & versa, aged rats with young partners lived longer than aged rats with aged partners, because in the second case the partners were often dying. Again with some copy-paste in the picture (and based on the 280 days decay of the two cohorts of rats, and a little math) it is (sadly) sufficient to explain the aged curves.

De : J Pedro Magalhaes À : Edouard Debonneuil ; Gerontology Research Group Envoyé le : Samedi 24 janvier 2015 13h55Objet : Re: [GRG] Dr Dhahbi’s Parabiosis article

I too am not convinced yet that parabiosis is affecting aging, even
if young blood may improve tissue regeneration. As you say, it could
be like growth hormone in having short-term benefits but long-term
be detrimental.
that said, there is an old paper suggesting parabiosis extends
lifespan in rats:http://ift.tt/1D3crNz

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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