Diphenhydramine and oxybutynin have anticholinergic effects, and just as many other anticholinergics are well known to produce significant cognitive side effects, especially pronounced in the elderly, so the report is not anything really new. Pro-cholinergic drugs (AChE inhibitors) are common anti-dementia drugs, indicating that stimulating the basal ganglia cholinergic system ameliorates dementia while antagonizing it increases the risk of dementia.
The fact that substitutes for the above drugs without anticholinergic effects are not associated with increased risk of dementia suggests that the association of anti-cholinergics with dementia is not a selection effect but rather is causative.
On Tue, Jan 27, 2015 at 1:18 AM, Paul Wakfer wrote:
On 15-01-26 08:30 PM, Craig Cooney wrote:
Nytol, Benadryl, Ditropan and Piriton among the medications identified by scientists as raising likelihood of dementiahttp://www.theguardian.com/society/2015/jan/27/sleeping-drugs-increased-risk-alzheimers
It may also be simply that the people who need these drugs in order to get a good night’s sleep are in a type of unhealthy state (for one reason or another) that is conducive to getting Alzheimers.
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