[GRG] Short corrected version. Re: Longevity lessons from Brandt’s bat, the little brown bat, and the naked mole-rat



I tend to agree that bats are
aging models that are overlooked, and I’ve been saying this for 20 years now.
And so have others, but somewhat indiscriminately on the basis of hibernating
bats banded in (say) Siberia. 

 

I also tend to agree with Greg that
looking at bats that undergo daily torpor and longer hibernation (basically
extended torpor) are less interesting from the aging point of view, as a large
part of their longevity is explained by the 1928 Pearl “rate of living theory.”
It’s not terribly interesting to humans unless they want to be astronauts, at
the same time as being unwilling to give up large fractions of
lifetime needed to travel long distances. And (of course) people who want
to see the future by effectively traveling in time past their allotted maximal
life span. But the ultimate goal of gerontology is have your cake and eat it,
too– you want to live longer than present human maximal life span AND be
healthy and awake for it.

 

I might add the basic fact that 30% of
bat species are vegetarian and live only on fruit and nectar.
A few drink blood. The other 70% are insectivores, and it’s only
in this class that temperature regulation goes by different rules, and resting
metabolic rates are lower than predicted by the Kleiber 3/4 exponent law for
body weight. Insects in the temperate zones of the world are very seasonal
and nocturnal, and thus are a variable food source, so temperate zone
insectivores (the two discussed in the lecture below, for example) NEED to
undergo diel torpor (“diapause”) and hibernation.

 

By contrast, in the tropics where all
the frugivores live, there is fruit available all year and at anytime of the day
(though frugivores may need to migrate to get it), so I am unaware of any
frugivore bat that undergoes torpor or hibernation in the wild (at least
three species do so in the lab when forced by lack or
food). Frugivores and nectarivores regulate their body temperatures (36-40
C) more closely, and have a higher BMR which is more or less predicted
by the Kleiber’s 3/4 power law, unlike the insectivores, which tend to fall
below the Kleiber prediction. So frugivore bats are like humans. (Frugivores
also keep blood sugar in the human diabetic range without suffering any diabetic
consequences, which is interesting.)

 

Frugivore bats also live a long time

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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