Re: [GRG] Bowheads, yawn.. Re: Longevity lessons from Brandt’s bat, the little brown bat, and the naked mole-rat

Dear all,
I should point out that the idea that metabolic rate negatively
correlates with longevity has now been disproved.  It’s not only
that bats and birds are an exception to the idea that high metabolic
rate is associated with short lifespan.  There is no correlation at
all between metabolic rate and longevity in mammals or birds.  we
have shown this, and so have others (Speakman, Austad, etc.):http://ift.tt/1D1DIlG
to repeat, Kleiber’s rule is wrong.
There is a small negative correlation between temperature and
longevity, however.  Could this be a contributing factor to the long
lifespan of the naked mole rat and, to a smaller degree, of the
bowhead whale?  yes, absolutely, but if you extrapolate from known
modulations of longevity by temperature in model systems it is a
relatively small contribution.  so the longevity of the naked mole
rat is still very interesting when compared to other rodents (but
maybe not as exceptional when compared to humans) and their cancer
resistance is fascinating.  As for the bowhead whale, as the longest
lived mammal, these animals must cope with a higher degree of damage
and insults over a longer period of time than any other mammalian
species, and I have no doubt that unraveling the mechanisms
responsible will be of great value to understand aging, longevity
and age-related diseases. this was why we went out to sequence the
genomes of the naked mole rat and bowhead whale:http://ift.tt/1D1DJG5
Lastly, my view is that species evolved different ‘tricks’ to have a
longer lifespan, and by discovering the ‘tricks’ used by the
bowhead, naked mole rats, bats, etc. we may be able to apply those
findings to humans in order to fight age-related diseases.  so
really what we need is to study multiple long-lived lineages.
Cheers,
JP
On 01/02/2015 03:16, sbharris1 wrote:

Greg, et al.

 

Bowheads don’t excite me for the same reason
that naked mole rats don’t. Large animals have slow metabolic
rates. Bowheads have only 1/3rd the metabolic rate you’d
expect for an animal of their size, possibly because they keep
their heat losses so low from all that blubber.

 

http://ift.tt/1ymJIzW

 

Bowheads are the second largest whale (only
blue whales are larger) and can get up to 50 to 100 tons. So
let’s say they weigh 1000 times what a human does. We’d expect
them to have a specific metabolic rate 1000^-(.25) = .178 that
of a human. If it’s really only 1/3 of what you’d expect from
the Kleiber equation that’s only 0.044 that of a human– down
in the reptilian range. Multiply that by 200 years and you get
only 9 years. Over a 200 year old lifespan a kg of bowhead
muscle burns only 10% of what kg of human muscle does.

 

Even using Kleiber, the bowhead MLS comes out
only 36 years. These are just really gigantic cows, like
elephants but bigger and longer lasting. The excitement of
scientists at their long life really mystifies me. Nobody gets
that excited over 200 year old tortoises, but the whales are
just as slow-motion when it comes to making calories.

 

I can’t grow to a size of 100 tons, or put on
that much blubber (though I admit I do find it chasing me).
The bowhead is not likely to have anything really interesting
in its slow cells. And if they can’t find any cancer in
bowheads, it’s because the ones they’ve seen are only 9 to 36
years old in human terms.

 

Sorry, it’s still the 100 year-old macaws that
interest me. Their cells have some trick that you’re
not likely to find in a whale, a mole rat, or even a bat. I
hope the simple math I’ve given has shown this.

 

Steve Harris

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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