Re: [GRG] Bowheads, yawn.. Re: Longevity lessons from Brandt’s bat, the little brown bat, and the naked mole-rat

On 02/01/2015 05:47 AM, J Pedro
Magalhaes wrote:

I
should point out that the idea that metabolic rate negatively
correlates with longevity has now been disproved.  It’s not only
that bats and birds are an exception to the idea that high
metabolic rate is associated with short lifespan.  There is no
correlation at all between metabolic rate and longevity in mammals
or birds.  we have shown this, and so have others (Speakman,
Austad, etc.):
http://ift.tt/1D1DIlG

to repeat, Kleiber’s rule is wrong.

What about this study that examines the combination of metabolic
rate and mitochondrial DNA base composition in mammals only?http://ift.tt/1BL2guM
In animal cells, mitochondria are semiautonomous organelles of
virtually “hostile” (bacterial) origin, with their own code and
genome (mtDNA). The semiautonomy and restricted resources could
result in occasional “conflicts of interests” with other cellular
components, in which mitochondria have greater chances to be “the
weakest link,” thus limiting longevity. Two principal questions are
addressed: (1) to what extent the mammalian maximum life span (MLS)
is associated with mtDNA base composition? (2) Does mtDNA base
composition correlate with another important mitochondria-associated
variable—resting metabolic rate (RMR)—and whether they complement
each other in determination of MLS? Analysis of 140 mammalian
species revealed significant correlations between MLS and the
content of the four mtDNA nucleotides, especially noted for GC pairs
(r2 = 0.42; p < 10−17). The most remarkable finding of this study
is that multivariate stepwise analysis selected only the GC content
and RMR, which together explained 77% of variation in MLS (p <
10−25). To the authors' knowledge, it is the highest coefficient of
MLS determination that has ever been reported for a comparable
sample size. Taking into account substantial errors in estimation of
MLS and RMR, it could mean that the GC and RMR explain most of the
MLS biological variation. Other putative players in MLS
determination should have relatively small contribution or their
effects should be realized via the same channels. Although further
research is clearly warranted, the extraordinary high correlation of
mtDNA GC and RMR with MLS suggests a “direct hitting” of the core
longevity targets, inferring mitochondria as a primary object for
longevity-promoting interventions.
Reason

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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