Re: [GRG] Bowheads, yawn.. Re: Longevity lessons from Brandt’s bat, the little brown bat, and the naked mole-rat

Steve,

 

Don’t yawn too soon.  Please bear in mind that bowheads DON’T hibernate, and are fully awake and functional and at normal body temperature all year round.  And they are mammals.  Therefore, they might have a secret for reducing metabolic rate that we can borrow.  Blubber is not their secret, something else is going on.  And metabolic rate or no metabolic rate, being free of cancer for 200 years seems like a good achievement.   As one aspect of this, cell division is considered risky for carcinogenesis, yet how many cell divisions does the Bowhead go through compared to us?  Not too shabby. 

 

And incidentally, the rate of living theory has been disproven.  Yes, it provides
interesitng rules of thumb, but it is not a true theory of aging, it is more of a way of making rough predictions and does not provide any mechanistic insights to speak of, so you should not put all your bets on it.

 

As for Mcaws:  of course!  By all means!  Let’s learn from them too.   

 

  Greg

On Sunday, February 1, 2015 7:58 AM, David Gobel wrote:

Fascinating! Perhaps
you would be interested in leading a crowdfunding effort to sequence the Macaw? I for one would love that!

DaveOn Saturday, January 31, 2015, sbharris1 wrote:

Greg, et al.

 

Bowheads don’t excite me for the same reason that naked mole
rats don’t. Large animals have slow metabolic rates. Bowheads have only 1/3rd
the metabolic rate you’d expect for an animal of their size, possibly because
they keep their heat losses so low from all that blubber.

 

http://ift.tt/1ymJIzW

 

Bowheads are the second largest whale (only blue whales are
larger) and can get up to 50 to 100 tons. So let’s say they weigh 1000 times
what a human does. We’d expect them to have a specific metabolic rate
1000^-(.25) = .178 that of a human. If it’s really only 1/3 of what you’d expect
from the Kleiber equation that’s only 0.044 that of a human– down in the
reptilian range. Multiply that by 200 years and you get only 9 years. Over a 200
year old lifespan a kg of bowhead muscle burns only 10% of what kg of
human muscle does.

 

Even using Kleiber, the bowhead MLS comes out only 36 years.
These are just really gigantic cows, like elephants but bigger and longer
lasting. The excitement of scientists at their long life really mystifies me.
Nobody gets that excited over 200 year old tortoises, but the whales are just as
slow-motion when it comes to making calories.

 

I can’t grow to a size of 100 tons, or put on that much
blubber (though I admit I do find it chasing me). The bowhead is not likely to
have anything really interesting in its slow cells. And if they can’t find any
cancer in bowheads, it’s because the ones they’ve seen are only 9 to 36 years
old in human terms.

 

Sorry, it’s still the 100 year-old macaws that
interest me. Their cells have some trick that you’re not likely to
find in a whale, a mole rat, or even a bat. I hope the simple math I’ve
given has shown this.

 

Steve Harris

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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