Re: [GRG] Longevity lessons from Brandt’s bat, the little brown bat, and the naked mole-rat

Robert,

 

I see an analogy between what you call programmed death and what I’m calling pro-aging processes, but I am thinking of things like the down-regulation of DNA repair and antioxidant defenses by IGF-1 early in development, which may have the effect of accelerating aging and speeding death in late life.  I think that by simply re-regulating such pro-aging pathways to a state that is more protective, we can in principle do much to intervene in human aging in a meaningful way.  Since I can’t think of any deep benefits of oxidative damage and DNA damage offhand, its seems like correcting this pro-aging state would not have to have much in the way of side effects, either.  The value of model systems like C. elegans in this regard is that they provide a proof of principle to the degree they can, in that blocking pro-aging pathways in C. elegans can increase the lifespan by a factor of 10.      

 

Greg

On Monday, February 2, 2015 3:55 PM, Robert Young wrote:

Greetings,

By “pro-aging processes” I assume you mean “programmed death,” which is common in many insects, annual plants,
etc.

Reversing the “low-hanging fruit” deaths attributed to these death programs is not really the fight against “intrinsic aging,” which is what concerns us humans. So, I agree that the life extension of such things as fruit flies and nematode worms doesn’t come close to comparing to what it will take to slow and eventually reverse the processes of intrinsic aging in mammals.

Sincerely,

Robert Young

From: Gregory M Fahy To: Gerontology Research Group Sent:
Monday, February 2, 2015 3:43 PMSubject: Re: [GRG] Longevity lessons from Brandt’s bat, the little brown bat, and the naked mole-rat

Johnny,

 

I believe Michael Rose would argue that longevity IS selected for, and in the case of the naked mole rat, which I believe does not show reduced fertility with age, the
longer they live, the more offspring they have, and so longevity should be selected for.  In a sense, the NMR is like the bowhead whale and the Mcaw in that all have virtually unlimited habitats:  the whale will never fill up the entire ocean, the NMR will never use up all the available dirt, and the Mccaw will never fill up the entire sky, so there is perhaps no imminent danger of destroying their own niches as a result of becoming very long lived and, as a result, overpopulating themselves to death. 

 

Most other species, though,
do have finite niche sizes, and so Josh Mittledorf would argue that senescence has been selected for to prevent niche destruction by overpopulation.  Which raises the question of whether humans may owe their great longevity compared to their nearest relatives at least in part to the fact that they can migrate and occupy every conceivable environment, thus making their niche virtually unbounded as well — well, for the first million years or so, anyway.  How this evolves is another question, but at least it’s food for thought. 

 

Most examples of big longevity gains seem to be the result of disrupting default pro-aging processes, and the logic of limiting population sizes might explain the existence of at least some active pro-aging processes whose abrogation may be the easiest way forward to human applications.  For more discussion,
see The Future of Aging.

 

— Greg  

On
Saturday, January 31, 2015 6:53 AM, “John M. “Johnny” Adams, GRG Exec Director” wrote:

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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