Dear GRG members,
It seems to me time has come to pool the life extension communities around the world to do an everolimus versus placebo testing on health in healthy persons, especially healthy elderlies.
Reactions to be expected but it seems to me it is the right time to do that. Given the scientific level here, I thought GRG would be a great place to shape the project. FAQ below.
— why everolimus: because it is an mTOR inhibitor like rapamycin and because mTOR inhibition is the most robust life extension technique so far (eg in mice it extends life even when started late in life) and because such low-risk-but-effective doses have been already established in healthy persons in various research studies (http://www.ncbi.nlm….ed/?term=rad001). The most well known is likely the recent 6-week use as a premedication to increase the response to the flu vaccine in elderlies (http://www.ncbi.nlm….pubmed/25540326)
— is it allowed? It would be best to do it in a legal way. Since there has been discussions on the matter over the years without answer, I suggest to start and to be receptive to propositions to make it well recognized along the way.
— how long would it last? what should we measure? We should typically report health (whenever we go to the doctor and report some health issue, have a sore throat, some flu, take some medicine…), during say one year before and then during the treatment. We should also indicate if we smoke/specific things that may make us healthy or not. The outcome would be a scoring system of health (eg counting 1 whenever we go to the doctor, take some medicine, etc.). Ideally we should report during say 5 years (epidemiologic studies of low-dose aspirin report positive results over 5 years)
— would the data be public? Yes but people will be defined by a nickname that they don’t use elsewhere so that their self-reporting is less biased by some potential avoidance to indicate bad health.
— who would pay? the people who take the placebo-or-drug.
— who would make the placebo-or-drug and send it? Logistics to be organized here.
FAQ (more general)
— For those who know me: what about mouse healthspan and lifespan tests?: I am not at all abandonning. In the contrary this human trial should provide light that human life extension solutions are happening now and that we should speed up the pipeline: speed up the check in mice of life extension properties that are believed from the litterature, and set controlled human trials.
— I think that what you propose is absolutely nonsense: no worry, indicate why precisely and we’ll see if some tradeoff makes more sense.