[GRG] Placebo-controlled, heath-primary-endpoint, everolimus crowtesting

Dear GRG members,

It seems to me time has come to pool the life extension communities around the world to do an everolimus versus placebo testing on health in healthy persons, especially healthy elderlies.

Reactions to be expected but it seems to me it is the right time to do that. Given the scientific level here, I thought GRG would be a great place to shape the project. FAQ below.

Cheers

Edouard

FAQ (technique)

— why everolimus: because it is an mTOR inhibitor like rapamycin and because mTOR inhibition is the most robust life extension technique so far (eg in mice it extends life even when started late in life) and because such low-risk-but-effective doses have been already established in healthy persons in various research studies (http://www.ncbi.nlm….ed/?term=rad001). The most well known is likely the recent 6-week use as a premedication to increase the response to the flu vaccine in elderlies (http://www.ncbi.nlm….pubmed/25540326)

 — is it allowed? It would be best to do it in a legal way. Since there has been discussions on the matter over the years without answer, I suggest to start and to be receptive to propositions to make it well recognized along the way.

 — how long would it last? what should we measure? We should typically report health (whenever we go to the doctor and report some health issue, have a sore throat, some flu, take some medicine…), during say one year before and then during the treatment. We should also indicate if we smoke/specific things that may make us healthy or not. The outcome would be a scoring system of health (eg counting 1 whenever we go to the doctor, take some medicine, etc.). Ideally we should report during say 5 years (epidemiologic studies of low-dose aspirin report positive results over 5 years)

 — would the data be public? Yes but people will be defined by a nickname that they don’t use elsewhere so that their self-reporting is less biased by some potential avoidance to indicate bad health.

 — who would pay? the people who take the placebo-or-drug.

 — who would make the placebo-or-drug and send it? Logistics to be organized here.

FAQ (more general)

— For those who know me: what about mouse healthspan and lifespan tests?: I am not at all abandonning. In the contrary this human trial should provide light that human life extension solutions are happening now and that we should speed up the pipeline: speed up the check in mice of life extension properties that are believed from the litterature, and set controlled human trials.

— I think that what you propose is absolutely nonsense: no worry, indicate why precisely and we’ll see if some tradeoff makes more sense.

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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