I read this interesting article issued by the Buck Institute
1: Removal of Senescent Cells from the body via a targeted therapy may potentially improve health span and could be a worthy focus for aging therapies.
2: Senescent cells secrete senescence-associated secretory phenotype or SASP which contain many factors, this SASP can influence nearby tissues and further drive aging.
3: It is hypothesized that SASP is what drives aging or age related conditions.
4: The Mayo Clinic did a test on genetically modified mice and it showed considerable improvement to health and tissue dysfunction. http://ift.tt/zy6O0Y
Whilst senescent cells are not the only type of damage aging causes I do feel it’s a worthy area to target with potential therapies.I could see such a therapy being followed up with rejuvenation of remaining cells or replacing lost cells via Stem cell therapy to improve tissue health.
How does the group feel about this research? Is anyone involved in this area of research and could perhaps tell us more?
The Buck institute is researching this area I believe funded by SENSRF and I think there are others investigating too but is this something the GRG could maybe assist with? Can we as a group potentially contribute and help push research forward faster?