The T Cell Scrubber is interesting though nothing much about it since 2010 has been heard due to it being shelved. Apparently Justin Rebo from SENS is working on a second generation version of the original and mentions on Longecity it should be done this year.
Perhaps this is a project that the GRG might be interested in assisting with? Senescent cells and SASP seem like a good target perhaps the GRG could team up with Buck and SENS?
From: Paul Wakfer To: email@example.com Sent: Monday, 9 February 2015, 23:05Subject: Re: [GRG] Cellular Senescence: senolysis
One important type of senescent cell that could be relatively easily
removed with a development that should require no additional FDA
approval would be the senescent white blood cells that are a major
factor in the reduction of immunity with age, and the consequent
reduced response to vaccines (essentially clogging up the white
blood cell reservoir).
The research findings foundation for this was presented to the SENS
2003 conference (or maybe it was 2002) already by Edith Effros and
this later became a SENS project (called Scruber) for some time, but
unfortunately seems to have been shelved by them. It involves using
equipment such as the Red Cross uses widely (to remove platlets and
other clotting factors from donors) to remove a person’s blood and
in some manner detect and remove the senescent cells before putting
the rest of the blood back into the person.
Hopefully this is one of the things that Buck is looking into and
will make available ASAP. Although I am highly cautious when it
comes to invasive therapies, I would definitely have this therapy
(even though my immunity still seems to be stellar at near age 77)
as soon as it is properly tested – and given that it is not unduly
costly. And I expect many thousands of others past 70 would also
have it once they understood its safety and importance for their
immunity – the reduced factor that is ultimately responsible for
most deaths via pneumonia.
The eventual home for *all* currently accessible, practically usable, scientifically evidential methods for increasing healthy longevity.
On 15-02-09 02:40 PM, Elliot Bergman wrote:
Some valuable thoughts here. I would guess that the Buck
project is small since it is funded by SENS-F , a relatively
small aging research non-profit organization. Do you know the
$-size of the SENS-F grant?
I suggest that you go straight to Buck’s senescence experts
(viz. Judy Campisi) & those at Mayo to elicit exactly how
they would translate this basic research into practical human
On Feb 9, 2015, at 3:32 PM, steve hill wrote:
read this interesting article issued by the Buck
Removal of Senescent Cells from the body via a
targeted therapy may potentially improve health span
and could be a worthy focus for aging therapies.
2: Senescent cells secrete senescence-associated
secretory phenotype or SASP which contain many
factors, this SASP can influence nearby tissues and
further drive aging.
3: It is
hypothesized that SASP is what drives aging or age
4: The Mayo
Clinic did a test on genetically modified mice and
it showed considerable improvement to health and
tissue dysfunction. http://ift.tt/zy6O0Y
Whilst senescent cells are not the
only type of damage aging causes I do feel it’s a
worthy area to target with potential therapies.I could
see such a therapy being followed up with rejuvenation
of remaining cells or replacing lost cells via Stem
cell therapy to improve tissue health.
How does the group feel about this
research? Is anyone involved in this area of research
and could perhaps tell us more?
The Buck institute is researching
this area I believe funded by SENSRF and I think there
are others investigating too but is this something the
GRG could maybe assist with? Can we as a group
potentially contribute and help push research forward