Re: [GRG] Cellular Senescence: senolysis

 

The T Cell Scrubber is interesting though nothing much about it since 2010 has been heard due to it being shelved. Apparently Justin Rebo from SENS is working on a second generation version of the original and mentions on Longecity it should be done this year.

 

Perhaps this is a project that the GRG might be interested in assisting with? Senescent cells and SASP seem like a good target perhaps the GRG could team up with Buck and SENS?

 

 

From: Paul Wakfer To: grg@lists.ucla.edu Sent: Monday, 9 February 2015, 23:05Subject: Re: [GRG] Cellular Senescence: senolysis

One important type of senescent cell that could be relatively easily
removed with a development that should require no additional FDA
approval would be the senescent white blood cells that are a major
factor in the reduction of immunity with age, and the consequent
reduced response to vaccines (essentially clogging up the white
blood cell reservoir).
The research findings foundation for this was presented to the SENS
2003 conference (or maybe it was 2002) already by Edith Effros and
this later became a SENS project (called Scruber) for some time, but
unfortunately seems to have been shelved by them. It involves using
equipment such as the Red Cross uses widely (to remove platlets and
other clotting factors from donors) to remove a person’s blood and
in some manner detect and remove the senescent cells before putting
the rest of the blood back into the person.
Hopefully this is one of the things that Buck is looking into and
will make available ASAP. Although I am highly cautious when it
comes to invasive therapies, I would definitely have this therapy
(even though my immunity still seems to be stellar at near age 77)
as soon as it is properly tested – and given that it is not unduly
costly. And I expect many thousands of others past 70 would also
have it once they understood its safety and importance for their
immunity – the reduced factor that is ultimately responsible for
most deaths via pneumonia.
–Paul Wakfer
http://Live120Plus.com
The eventual home for *all* currently accessible, practically usable, scientifically evidential methods for increasing healthy longevity.

On 15-02-09 02:40 PM, Elliot Bergman wrote:
Dear Steve:

Some valuable thoughts here. I would guess that the Buck
project is small since it is funded by SENS-F , a relatively
small aging research non-profit organization. Do you know the
$-size of the SENS-F grant?

I suggest that you go straight to Buck’s senescence experts
(viz. Judy Campisi) & those at Mayo to elicit exactly how
they would translate this basic research into practical human
clinical applications.

Respectfully,

Elliot

On Feb 9, 2015, at 3:32 PM, steve hill wrote:

Good
evening,

I
read this interesting article issued by the Buck
Institute 

http://ift.tt/1A5jbgK

In
summary:

1:
Removal of Senescent Cells from the body via a
targeted therapy may potentially improve health span
and could be a worthy focus for aging therapies. 

2: Senescent cells secrete senescence-associated
secretory phenotype or SASP which contain many
factors, this SASP can influence nearby tissues and
further drive aging.

3: It is
hypothesized that SASP is what drives aging or age
related conditions. 

4: The Mayo
Clinic did a test on genetically modified mice and
it showed considerable improvement to health and
tissue dysfunction. http://ift.tt/zy6O0Y

Whilst senescent cells are not the
only type of damage aging causes I do feel it’s a
worthy area to target with potential therapies.I could
see such a therapy being followed up with rejuvenation
of remaining cells or replacing lost cells via Stem
cell therapy to improve tissue health.

How does the group feel about this
research? Is anyone involved in this area of research
and could perhaps tell us more?

The Buck institute is researching
this area I believe funded by SENSRF and I think there
are others investigating too but is this something the
GRG could maybe assist with? Can we as a group
potentially contribute and help push research forward
faster?

Regards

Steve

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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