Re: [GRG] Is the Secret to Longevity Available from this Website? | MIT Technology Review

On 15-02-10 11:13 AM, Anthony Loera wrote:
Hi Anthony,

Wouldn’t NAD be better than Nicotinamide Riboside
from chromadex, which is what this product contains?

Although the LEF product that I am taking contains nicotinamine
riboside (NR) as a registered trademarked product NIAGEN produced by
the Chromadex company, I doubt that the Elysium Health product will
contain NIAGEN. Nicotinamide is produced in the human body on the
path to making NAD and is not patentable as a chemical, as I
understand things (certainly as they should be!). Although a use
patent could be obtained for some disease or dysfunction defined by
the FDA, that is not what Elysium Health is promoting it for. There
are many possible sources of NR. The only reason I have waited for
NR to become available from some US supplement supplier is because
it takes a lot of time effort and capital to import a supply from
China or elsewhere, and no chemical supplier in the US or Canada
would sell me any as an individual, particularly not for personal
use. Several other such chemicals, I did not wait for, but this one
I decided to do so, partly because of the lack of clear research for
benefits greater than NAD or simply taking more niacin.
Note that I erred previously (skimmed too much) by not reading the
full paragraph:
“Guarente says Elysium’s pill includes a precursor to NAD, called
nicotinamide riboside, which the body can transform into NAD and put
to use. In addition, the pill contains pterostilbene, an antioxidant
that Guarente says stimulates sirtuins in a different way. Both
ingredients can already be found in specialty vitamins.  “We expect
a synergistic effect [from] combining them,†he says.”
which makes it very clear that the Elysium Health product contains
both NR and pterostilbene, the same as the LEF product. Since both
of these are available from Chromadex, perhaps the Elysium Health
product does use ingredients from them. In which case Elysium Health
is counting on the scientific reputations of its owners to
competitively sell more product than other supplement suppliers such
as LEF who already have essentially the same product available.
As for taking NAD directly, this had been tried many ways for
decades and it appears that it does not survived digestion (and is
no better that taking nicotinamide) when orally ingested. Even used
sublingually its benefit is has no clear evidence (I have also taken
sublingual NADH for many, many years).
Sorry but I don’t have time to provide references, but I am sure you
can find them by searching and the LERDIT development wiki page that
I made public and to which I gave the link in another reply will
likely have some of this information on it.
–Paul Wakfer
The eventual home for *all* currently accessible, practically usable, scientifically evidential methods for increasing healthy longevity.

On Feb 3, 2015 12:30 PM, “Steven Charlap,
I would be
interested to get the group’s perspective on this product.


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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